A unified architecture of transcriptional regulatory elements
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A unified architecture of transcriptional regulatory elements. / Andersson, Robin; Sandelin, Albin Gustav; Danko, Charles G.
In: Trends in Genetics, Vol. 31, No. 8, 08.2015, p. 426-433.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A unified architecture of transcriptional regulatory elements
AU - Andersson, Robin
AU - Sandelin, Albin Gustav
AU - Danko, Charles G.
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/8
Y1 - 2015/8
N2 - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.
AB - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.
U2 - 10.1016/j.tig.2015.05.007
DO - 10.1016/j.tig.2015.05.007
M3 - Journal article
C2 - 26073855
VL - 31
SP - 426
EP - 433
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 8
ER -
ID: 141985309