A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview
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A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis : overview. / Marrie, Ruth Ann; Cohen, Jeffrey; Stuve, Olaf; Trojano, Maria; Sørensen, Per Soelberg; Reingold, Stephen; Cutter, Gary; Reider, Nadia.
In: Multiple Sclerosis Journal, Vol. 21, No. 3, 03.2015, p. 263-81.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis
T2 - overview
AU - Marrie, Ruth Ann
AU - Cohen, Jeffrey
AU - Stuve, Olaf
AU - Trojano, Maria
AU - Sørensen, Per Soelberg
AU - Reingold, Stephen
AU - Cutter, Gary
AU - Reider, Nadia
N1 - © The Author(s), 2015.
PY - 2015/3
Y1 - 2015/3
N2 - BACKGROUND: Comorbidity is an area of increasing interest in multiple sclerosis (MS).OBJECTIVE: The objective of this review is to estimate the incidence and prevalence of comorbidity in people with MS and assess the quality of included studies.METHODS: We searched the PubMed, SCOPUS, EMBASE and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles. Two reviewers independently screened abstracts. One reviewer abstracted data using a standardized form and the abstraction was verified by a second reviewer. We assessed study quality using a standardized approach. We quantitatively assessed population-based studies using the I² statistic, and conducted random-effects meta-analyses.RESULTS: We included 249 articles. Study designs were variable with respect to source populations, case definitions, methods of ascertainment and approaches to reporting findings. Prevalence was reported more frequently than incidence; estimates for prevalence and incidence varied substantially for all conditions. Heterogeneity was high.CONCLUSION: This review highlights substantial gaps in the epidemiological knowledge of comorbidity in MS worldwide. Little is known about comorbidity in Central or South America, Asia or Africa. Findings in North America and Europe are inconsistent. Future studies should report age-, sex- and ethnicity-specific estimates of incidence and prevalence, and standardize findings to a common population.
AB - BACKGROUND: Comorbidity is an area of increasing interest in multiple sclerosis (MS).OBJECTIVE: The objective of this review is to estimate the incidence and prevalence of comorbidity in people with MS and assess the quality of included studies.METHODS: We searched the PubMed, SCOPUS, EMBASE and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles. Two reviewers independently screened abstracts. One reviewer abstracted data using a standardized form and the abstraction was verified by a second reviewer. We assessed study quality using a standardized approach. We quantitatively assessed population-based studies using the I² statistic, and conducted random-effects meta-analyses.RESULTS: We included 249 articles. Study designs were variable with respect to source populations, case definitions, methods of ascertainment and approaches to reporting findings. Prevalence was reported more frequently than incidence; estimates for prevalence and incidence varied substantially for all conditions. Heterogeneity was high.CONCLUSION: This review highlights substantial gaps in the epidemiological knowledge of comorbidity in MS worldwide. Little is known about comorbidity in Central or South America, Asia or Africa. Findings in North America and Europe are inconsistent. Future studies should report age-, sex- and ethnicity-specific estimates of incidence and prevalence, and standardize findings to a common population.
KW - Comorbidity
KW - Humans
KW - Incidence
KW - Multiple Sclerosis
KW - Prevalence
U2 - 10.1177/1352458514564491
DO - 10.1177/1352458514564491
M3 - Review
C2 - 25623244
VL - 21
SP - 263
EP - 281
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 3
ER -
ID: 162378741