A spatiotemporal atlas of mouse liver homeostasis and regeneration

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A spatiotemporal atlas of mouse liver homeostasis and regeneration. / Xu, Jiangshan; Guo, Pengcheng; Hao, Shijie; Shangguan, Shuncheng; Shi, Quan; Volpe, Giacomo; Huang, Keke; Zuo, Jing; An, Juan; Yuan, Yue; Cheng, Mengnan; Deng, Qiuting; Zhang, Xiao; Lai, Guangyao; Nan, Haitao; Wu, Baihua; Shentu, Xinyi; Wu, Liang; Wei, Xiaoyu; Jiang, Yujia; Huang, Xin; Pan, Fengyu; Song, Yumo; Li, Ronghai; Wang, Zhifeng; Liu, Chuanyu; Liu, Shiping; Li, Yuxiang; Yang, Tao; Xu, Zhicheng; Du, Wensi; Li, Ling; Ahmed, Tanveer; You, Kai; Dai, Zhen; Li, Li; Qin, Baoming; Li, Yinxiong; Lai, Liangxue; Qin, Dajiang; Chen, Junling; Fan, Rong; Li, Yongyin; Hou, Jinlin; Ott, Michael; Sharma, Amar Deep; Cantz, Tobias; Schambach, Axel; Kristiansen, Karsten; Hutchins, Andrew P.; Göttgens, Berthold; Maxwell, Patrick H.; Hui, Lijian; Xu, Xun; Liu, Longqi; Chen, Ao; Lai, Yiwei; Esteban, Miguel A.

In: Nature Genetics, Vol. 56, 2024, p. 953-969.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xu, J, Guo, P, Hao, S, Shangguan, S, Shi, Q, Volpe, G, Huang, K, Zuo, J, An, J, Yuan, Y, Cheng, M, Deng, Q, Zhang, X, Lai, G, Nan, H, Wu, B, Shentu, X, Wu, L, Wei, X, Jiang, Y, Huang, X, Pan, F, Song, Y, Li, R, Wang, Z, Liu, C, Liu, S, Li, Y, Yang, T, Xu, Z, Du, W, Li, L, Ahmed, T, You, K, Dai, Z, Li, L, Qin, B, Li, Y, Lai, L, Qin, D, Chen, J, Fan, R, Li, Y, Hou, J, Ott, M, Sharma, AD, Cantz, T, Schambach, A, Kristiansen, K, Hutchins, AP, Göttgens, B, Maxwell, PH, Hui, L, Xu, X, Liu, L, Chen, A, Lai, Y & Esteban, MA 2024, 'A spatiotemporal atlas of mouse liver homeostasis and regeneration', Nature Genetics, vol. 56, pp. 953-969. https://doi.org/10.1038/s41588-024-01709-7

APA

Xu, J., Guo, P., Hao, S., Shangguan, S., Shi, Q., Volpe, G., Huang, K., Zuo, J., An, J., Yuan, Y., Cheng, M., Deng, Q., Zhang, X., Lai, G., Nan, H., Wu, B., Shentu, X., Wu, L., Wei, X., ... Esteban, M. A. (2024). A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nature Genetics, 56, 953-969. https://doi.org/10.1038/s41588-024-01709-7

Vancouver

Xu J, Guo P, Hao S, Shangguan S, Shi Q, Volpe G et al. A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nature Genetics. 2024;56:953-969. https://doi.org/10.1038/s41588-024-01709-7

Author

Xu, Jiangshan ; Guo, Pengcheng ; Hao, Shijie ; Shangguan, Shuncheng ; Shi, Quan ; Volpe, Giacomo ; Huang, Keke ; Zuo, Jing ; An, Juan ; Yuan, Yue ; Cheng, Mengnan ; Deng, Qiuting ; Zhang, Xiao ; Lai, Guangyao ; Nan, Haitao ; Wu, Baihua ; Shentu, Xinyi ; Wu, Liang ; Wei, Xiaoyu ; Jiang, Yujia ; Huang, Xin ; Pan, Fengyu ; Song, Yumo ; Li, Ronghai ; Wang, Zhifeng ; Liu, Chuanyu ; Liu, Shiping ; Li, Yuxiang ; Yang, Tao ; Xu, Zhicheng ; Du, Wensi ; Li, Ling ; Ahmed, Tanveer ; You, Kai ; Dai, Zhen ; Li, Li ; Qin, Baoming ; Li, Yinxiong ; Lai, Liangxue ; Qin, Dajiang ; Chen, Junling ; Fan, Rong ; Li, Yongyin ; Hou, Jinlin ; Ott, Michael ; Sharma, Amar Deep ; Cantz, Tobias ; Schambach, Axel ; Kristiansen, Karsten ; Hutchins, Andrew P. ; Göttgens, Berthold ; Maxwell, Patrick H. ; Hui, Lijian ; Xu, Xun ; Liu, Longqi ; Chen, Ao ; Lai, Yiwei ; Esteban, Miguel A. / A spatiotemporal atlas of mouse liver homeostasis and regeneration. In: Nature Genetics. 2024 ; Vol. 56. pp. 953-969.

Bibtex

@article{64e48e396ef5468d8d4103fccee3c7c5,

title = "A spatiotemporal atlas of mouse liver homeostasis and regeneration",

abstract = "The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale. Our integrative study dissects in detail the molecular gradients controlling liver cell function, systematically defining how gene networks are dynamically modulated through intercellular communication to promote regeneration. Among other important regulators, we identified the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/β-catenin signaling for facilitating hepatocyte proliferation. Our data and analytical pipelines lay the foundation for future high-definition tissue-scale atlases of organ physiology and malfunction.",

author = "Jiangshan Xu and Pengcheng Guo and Shijie Hao and Shuncheng Shangguan and Quan Shi and Giacomo Volpe and Keke Huang and Jing Zuo and Juan An and Yue Yuan and Mengnan Cheng and Qiuting Deng and Xiao Zhang and Guangyao Lai and Haitao Nan and Baihua Wu and Xinyi Shentu and Liang Wu and Xiaoyu Wei and Yujia Jiang and Xin Huang and Fengyu Pan and Yumo Song and Ronghai Li and Zhifeng Wang and Chuanyu Liu and Shiping Liu and Yuxiang Li and Tao Yang and Zhicheng Xu and Wensi Du and Ling Li and Tanveer Ahmed and Kai You and Zhen Dai and Li Li and Baoming Qin and Yinxiong Li and Liangxue Lai and Dajiang Qin and Junling Chen and Rong Fan and Yongyin Li and Jinlin Hou and Michael Ott and Sharma, {Amar Deep} and Tobias Cantz and Axel Schambach and Karsten Kristiansen and Hutchins, {Andrew P.} and Berthold G{\"o}ttgens and Maxwell, {Patrick H.} and Lijian Hui and Xun Xu and Longqi Liu and Ao Chen and Yiwei Lai and Esteban, {Miguel A.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.",

year = "2024",

doi = "10.1038/s41588-024-01709-7",

language = "English",

volume = "56",

pages = "953--969",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A spatiotemporal atlas of mouse liver homeostasis and regeneration

AU - Xu, Jiangshan

AU - Guo, Pengcheng

AU - Hao, Shijie

AU - Shangguan, Shuncheng

AU - Shi, Quan

AU - Volpe, Giacomo

AU - Huang, Keke

AU - Zuo, Jing

AU - An, Juan

AU - Yuan, Yue

AU - Cheng, Mengnan

AU - Deng, Qiuting

AU - Zhang, Xiao

AU - Lai, Guangyao

AU - Nan, Haitao

AU - Wu, Baihua

AU - Shentu, Xinyi

AU - Wu, Liang

AU - Wei, Xiaoyu

AU - Jiang, Yujia

AU - Huang, Xin

AU - Pan, Fengyu

AU - Song, Yumo

AU - Li, Ronghai

AU - Wang, Zhifeng

AU - Liu, Chuanyu

AU - Liu, Shiping

AU - Li, Yuxiang

AU - Yang, Tao

AU - Xu, Zhicheng

AU - Du, Wensi

AU - Li, Ling

AU - Ahmed, Tanveer

AU - You, Kai

AU - Dai, Zhen

AU - Li, Li

AU - Qin, Baoming

AU - Li, Yinxiong

AU - Lai, Liangxue

AU - Qin, Dajiang

AU - Chen, Junling

AU - Fan, Rong

AU - Li, Yongyin

AU - Hou, Jinlin

AU - Ott, Michael

AU - Sharma, Amar Deep

AU - Cantz, Tobias

AU - Schambach, Axel

AU - Kristiansen, Karsten

AU - Hutchins, Andrew P.

AU - Göttgens, Berthold

AU - Maxwell, Patrick H.

AU - Hui, Lijian

AU - Xu, Xun

AU - Liu, Longqi

AU - Chen, Ao

AU - Lai, Yiwei

AU - Esteban, Miguel A.

PY - 2024

Y1 - 2024

N2 - The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale. Our integrative study dissects in detail the molecular gradients controlling liver cell function, systematically defining how gene networks are dynamically modulated through intercellular communication to promote regeneration. Among other important regulators, we identified the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/β-catenin signaling for facilitating hepatocyte proliferation. Our data and analytical pipelines lay the foundation for future high-definition tissue-scale atlases of organ physiology and malfunction.

AB - The mechanism by which mammalian liver cell responses are coordinated during tissue homeostasis and perturbation is poorly understood, representing a major obstacle in our understanding of many diseases. This knowledge gap is caused by the difficulty involved with studying multiple cell types in different states and locations, particularly when these are transient. We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of mouse liver homeostasis and regeneration at the whole-lobe scale. Our integrative study dissects in detail the molecular gradients controlling liver cell function, systematically defining how gene networks are dynamically modulated through intercellular communication to promote regeneration. Among other important regulators, we identified the transcriptional cofactor TBL1XR1 as a rheostat linking inflammation to Wnt/β-catenin signaling for facilitating hepatocyte proliferation. Our data and analytical pipelines lay the foundation for future high-definition tissue-scale atlases of organ physiology and malfunction.

U2 - 10.1038/s41588-024-01709-7

DO - 10.1038/s41588-024-01709-7

M3 - Journal article

C2 - 38627598

AN - SCOPUS:85190697199

VL - 56

SP - 953

EP - 969

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

ER -

ID: 391160870

Forskning