A population of stem cells with strong regenerative potential discovered in deer antlers
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
A population of stem cells with strong regenerative potential discovered in deer antlers. / Qin, Tao; Zhang, Guokun; Zheng, Yi; Li, Shengyou; Yuan, Yuan; Li, Qingjie; Hu, Mingliang; Si, Huazhe; Wei, Guanning; Gao, Xueli; Cui, Xinxin; Xia, Bing; Ren, Jing; Wang, Kun; Ba, Hengxing; Liu, Zhen; Heller, Rasmus; Li, Zhipeng; Wang, Wen; Huang, Jinghui; Li, Chunyi; Qiu, Qiang.
In: Science (New York, N.Y.), Vol. 379, No. 6634, 2023, p. 840-847.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A population of stem cells with strong regenerative potential discovered in deer antlers
AU - Qin, Tao
AU - Zhang, Guokun
AU - Zheng, Yi
AU - Li, Shengyou
AU - Yuan, Yuan
AU - Li, Qingjie
AU - Hu, Mingliang
AU - Si, Huazhe
AU - Wei, Guanning
AU - Gao, Xueli
AU - Cui, Xinxin
AU - Xia, Bing
AU - Ren, Jing
AU - Wang, Kun
AU - Ba, Hengxing
AU - Liu, Zhen
AU - Heller, Rasmus
AU - Li, Zhipeng
AU - Wang, Wen
AU - Huang, Jinghui
AU - Li, Chunyi
AU - Qiu, Qiang
PY - 2023
Y1 - 2023
N2 - The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of "antler blastema progenitor cells" (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.
AB - The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of "antler blastema progenitor cells" (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.
U2 - 10.1126/science.add0488
DO - 10.1126/science.add0488
M3 - Journal article
C2 - 36821675
AN - SCOPUS:85148679947
VL - 379
SP - 840
EP - 847
JO - Science
JF - Science
SN - 0036-8075
IS - 6634
ER -
ID: 338525003