A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors
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A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors. / Huang, WeiSun; Hu, Shengjie; Jiang, Xuecheng; Weng, Yuyan; Liu, Yu; Tang, Xue; Yang, Guofeng; Wang, Xun; Lu, Naiyan.
In: Nanotechnology, Vol. 34, No. 31, 315203, 30.07.2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A highly sensitive sensor for carcinoembryonic antigen based on AlGaN/GaN high-electron-mobility transistors
AU - Huang, WeiSun
AU - Hu, Shengjie
AU - Jiang, Xuecheng
AU - Weng, Yuyan
AU - Liu, Yu
AU - Tang, Xue
AU - Yang, Guofeng
AU - Wang, Xun
AU - Lu, Naiyan
PY - 2023/7/30
Y1 - 2023/7/30
N2 - Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.
AB - Carcinoembryonic antigen (CEA) is a well-known biomarker and validated serum biomarker for lung cancer. We introduce a simple label-free method for CEA detection. Specific recognition of CEA was made possible by immobilizing CEA antibodies in the sensing region of AlGaN/GaN high-electron-mobility transistors. The biosensors have a detection limit of 1 fg ml(-1) in phosphate buffer solution. This approach has advantages of integration, miniaturization, low cost, and rapid detection compared to other testing methods for lung cancer and could be used in future medical diagnostics.
KW - AlGaN
KW - GaN HEMT
KW - biosensor
KW - CEA
KW - lung cancer screening
KW - CANCER STATISTICS
KW - LUNG-CANCER
KW - BIOMARKERS
U2 - 10.1088/1361-6528/acd1f2
DO - 10.1088/1361-6528/acd1f2
M3 - Journal article
C2 - 37137294
VL - 34
JO - Nanotechnology
JF - Nanotechnology
SN - 0957-4484
IS - 31
M1 - 315203
ER -
ID: 347790240