A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
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A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites. / Rose, Christian S; Ek, Jakob; Urhammer, Søren A; Glümer, Charlotte; Borch-Johnsen, Knut; Jørgensen, Torben; Pedersen, Oluf; Hansen, Torben.
In: Diabetes, Vol. 54, No. 10, 2005, p. 3026-31.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites
AU - Rose, Christian S
AU - Ek, Jakob
AU - Urhammer, Søren A
AU - Glümer, Charlotte
AU - Borch-Johnsen, Knut
AU - Jørgensen, Torben
AU - Pedersen, Oluf
AU - Hansen, Torben
PY - 2005
Y1 - 2005
N2 - A graded relationship has been reported between fasting and postprandial plasma glucose levels and the subsequent risk of cardiovascular morbidity and mortality. We hypothesized that the GCK -30G>A promoter polymorphism is associated with elevated glycemia in the middle-aged general population of whites, as well as with features of the World Health Organization (WHO)-defined metabolic syndrome. The GCK -30G>A polymorphism was genotyped in the population-based Inter99 study cohort (5,965 subjects) and in 332 nondiabetic subjects and 1,063 patients with type 2 diabetes. In the Inter99 cohort, the GCK -30A allele was associated with increased fasting (P <0.001) and post-oral glucose tolerance test (OGTT) plasma glucose levels (P <0.001), and in the same cohort, the GCK -30A allele was more frequent among 1,325 subjects with the metabolic syndrome than among 1,679 subjects without any components of the metabolic syndrome (P = 0.002). Moreover, the GCK -30A allele frequency was higher among 2,587 subjects with impaired glucose regulation (IGR) than among 4,773 glucose-tolerant subjects (17.3% [95% CI 16.2-18.3] vs. 15.0% [14.3-15.7], P <0.001, odds ratio GG vs. GA 1.21 [1.08-1.36], GG vs. AA 1.62 [1.17-2.24]). In conclusion, the GCK -30G>A polymorphism associates with elevated fasting and post-OGTT glycemia in the middle-aged general population of whites, as well as with IGR and other features of the WHO-defined metabolic syndrome.
AB - A graded relationship has been reported between fasting and postprandial plasma glucose levels and the subsequent risk of cardiovascular morbidity and mortality. We hypothesized that the GCK -30G>A promoter polymorphism is associated with elevated glycemia in the middle-aged general population of whites, as well as with features of the World Health Organization (WHO)-defined metabolic syndrome. The GCK -30G>A polymorphism was genotyped in the population-based Inter99 study cohort (5,965 subjects) and in 332 nondiabetic subjects and 1,063 patients with type 2 diabetes. In the Inter99 cohort, the GCK -30A allele was associated with increased fasting (P <0.001) and post-oral glucose tolerance test (OGTT) plasma glucose levels (P <0.001), and in the same cohort, the GCK -30A allele was more frequent among 1,325 subjects with the metabolic syndrome than among 1,679 subjects without any components of the metabolic syndrome (P = 0.002). Moreover, the GCK -30A allele frequency was higher among 2,587 subjects with impaired glucose regulation (IGR) than among 4,773 glucose-tolerant subjects (17.3% [95% CI 16.2-18.3] vs. 15.0% [14.3-15.7], P <0.001, odds ratio GG vs. GA 1.21 [1.08-1.36], GG vs. AA 1.62 [1.17-2.24]). In conclusion, the GCK -30G>A polymorphism associates with elevated fasting and post-OGTT glycemia in the middle-aged general population of whites, as well as with IGR and other features of the WHO-defined metabolic syndrome.
KW - Adult
KW - Alleles
KW - Anthropometry
KW - Blood Glucose
KW - Case-Control Studies
KW - European Continental Ancestry Group
KW - Fasting
KW - Food
KW - Gene Frequency
KW - Genotype
KW - Glucokinase
KW - Glucose Tolerance Test
KW - Humans
KW - Hyperglycemia
KW - Islets of Langerhans
KW - Metabolic Syndrome X
KW - Middle Aged
KW - Polymorphism, Genetic
KW - Promoter Regions, Genetic
KW - World Health Organization
M3 - Journal article
C2 - 16186409
VL - 54
SP - 3026
EP - 3031
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 10
ER -
ID: 38455685