99mTc-d,l-HMPAO and SPECT of the brain in normal aging
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99mTc-d,l-HMPAO and SPECT of the brain in normal aging. / Waldemar, G; Hasselbalch, S G; Andersen, A R; Delecluse, F; Petersen, P; Johnsen, A; Paulson, O B.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 11, No. 3, 05.1991, p. 508-21.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 99mTc-d,l-HMPAO and SPECT of the brain in normal aging
AU - Waldemar, G
AU - Hasselbalch, S G
AU - Andersen, A R
AU - Delecluse, F
AU - Petersen, P
AU - Johnsen, A
AU - Paulson, O B
PY - 1991/5
Y1 - 1991/5
N2 - Single photon emission computed tomography (SPECT) with 99mTc-d,l-hexamethylpropyleneamine oxime (99mTc-d,l-HMPAO) was used to determine global and regional CBF in 53 healthy subjects aged 21-83 years. For the whole group, global CBF normalized to the cerebellum was 86.4% +/- 8.4 (SD). The contribution of age, sex, and atrophy to variations in global CBF was studied using stepwise multiple regression analysis. There was a significant negative correlation of global CBF with subjective ratings of cortical atrophy, but not with ratings of ventricular size, Evans ratio, sex, or age. In a subgroup of 33 subjects, in whom volumetric measurements of atrophy were performed, cortical atrophy was the only significant determinant for global CBF, accounting for 27% of its variance. Mean global CBF as measured with the 133Xe inhalation technique and SPECT was 54 +/- 9 ml/100 g/min and did not correlate significantly with age. There was a preferential decline of CBF in the frontal cortex with advancing age. The side-to-side asymmetry of several regions of interest increased with age. A method was described for estimation of subcortical CBF, which decreased with advancing cortical atrophy. The relative area of the subcortical low-flow region increased with age. These results are useful in distinguishing the effects of age and simple atrophy from disease effects, when the 99mTc-d,l-HMPAO method is used.
AB - Single photon emission computed tomography (SPECT) with 99mTc-d,l-hexamethylpropyleneamine oxime (99mTc-d,l-HMPAO) was used to determine global and regional CBF in 53 healthy subjects aged 21-83 years. For the whole group, global CBF normalized to the cerebellum was 86.4% +/- 8.4 (SD). The contribution of age, sex, and atrophy to variations in global CBF was studied using stepwise multiple regression analysis. There was a significant negative correlation of global CBF with subjective ratings of cortical atrophy, but not with ratings of ventricular size, Evans ratio, sex, or age. In a subgroup of 33 subjects, in whom volumetric measurements of atrophy were performed, cortical atrophy was the only significant determinant for global CBF, accounting for 27% of its variance. Mean global CBF as measured with the 133Xe inhalation technique and SPECT was 54 +/- 9 ml/100 g/min and did not correlate significantly with age. There was a preferential decline of CBF in the frontal cortex with advancing age. The side-to-side asymmetry of several regions of interest increased with age. A method was described for estimation of subcortical CBF, which decreased with advancing cortical atrophy. The relative area of the subcortical low-flow region increased with age. These results are useful in distinguishing the effects of age and simple atrophy from disease effects, when the 99mTc-d,l-HMPAO method is used.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aging/physiology
KW - Atrophy
KW - Brain/blood supply
KW - Cerebellum/blood supply
KW - Cerebral Cortex/pathology
KW - Cerebrovascular Circulation
KW - Female
KW - Frontal Lobe/blood supply
KW - Humans
KW - Male
KW - Middle Aged
KW - Organotechnetium Compounds
KW - Oximes
KW - Technetium Tc 99m Exametazime
KW - Tomography, Emission-Computed, Single-Photon
KW - Xenon Radioisotopes
U2 - 10.1038/jcbfm.1991.95
DO - 10.1038/jcbfm.1991.95
M3 - Journal article
C2 - 2016360
VL - 11
SP - 508
EP - 521
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 3
ER -
ID: 275029548