[99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee
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[99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee. / Hansen, E S; Søballe, K; Henriksen, T B; Hjortdal, V E; Bünger, C.
In: Journal of Orthopaedic Research, Vol. 9, No. 2, 03.1991, p. 191-202.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - [99mTc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee
AU - Hansen, E S
AU - Søballe, K
AU - Henriksen, T B
AU - Hjortdal, V E
AU - Bünger, C
PY - 1991/3
Y1 - 1991/3
N2 - The relationship between [99mTc]diphosphonate uptake and bone hemodynamics was studied in canine carrageenan-induced juvenile chronic arthritis. Blood flow was determined with microspheres, plasma and red cell volumes were measured by labeled fibrinogen and red cells, and the microvascular volume and mean transit time of blood were calculated. Normal femoral epiphyses had lower central and higher subchondral blood flow and diphosphonate uptake values. Epiphyseal vascular volume was uniform, resulting in a greater transit time of blood centrally. In arthritis, blood flow and diphosphonate uptake were increased subchondrally and unaffected centrally, while epiphyseal vascular volume was increased throughout, leading to prolonged transit time centrally. The normal metaphyses had low blood flow and diphosphonate uptake values in cancellous bone and very high values in growth plates, but a large vascular volume throughout. The mean transit time therefore was low in growth plates and high in adjacent cancellous bone. Arthritis caused decreased blood flow and diphosphonate uptake in growth plates but increased vascular volume and transit time of blood. Diphosphonate uptake correlated positively with blood flow and plasma volume and negatively with red cell volume in a nonlinear fashion. Thus, changes in diphosphonate uptake and microvascular hemodynamics occur in both epiphyseal and metaphyseal bone in chronic synovitis of the immature knee. The [99mTc]diphosphonate bone scan seems to reflect blood flow, plasma volume, and red cell volume of bone.
AB - The relationship between [99mTc]diphosphonate uptake and bone hemodynamics was studied in canine carrageenan-induced juvenile chronic arthritis. Blood flow was determined with microspheres, plasma and red cell volumes were measured by labeled fibrinogen and red cells, and the microvascular volume and mean transit time of blood were calculated. Normal femoral epiphyses had lower central and higher subchondral blood flow and diphosphonate uptake values. Epiphyseal vascular volume was uniform, resulting in a greater transit time of blood centrally. In arthritis, blood flow and diphosphonate uptake were increased subchondrally and unaffected centrally, while epiphyseal vascular volume was increased throughout, leading to prolonged transit time centrally. The normal metaphyses had low blood flow and diphosphonate uptake values in cancellous bone and very high values in growth plates, but a large vascular volume throughout. The mean transit time therefore was low in growth plates and high in adjacent cancellous bone. Arthritis caused decreased blood flow and diphosphonate uptake in growth plates but increased vascular volume and transit time of blood. Diphosphonate uptake correlated positively with blood flow and plasma volume and negatively with red cell volume in a nonlinear fashion. Thus, changes in diphosphonate uptake and microvascular hemodynamics occur in both epiphyseal and metaphyseal bone in chronic synovitis of the immature knee. The [99mTc]diphosphonate bone scan seems to reflect blood flow, plasma volume, and red cell volume of bone.
KW - Animals
KW - Arthritis/physiopathology
KW - Carrageenan
KW - Diphosphonates
KW - Dogs
KW - Epiphyses/metabolism
KW - Femur/blood supply
KW - Growth Plate/metabolism
KW - Hematocrit
KW - Hemodynamics
KW - Knee Joint/metabolism
KW - Regional Blood Flow
KW - Technetium
KW - Technetium Compounds
U2 - 10.1002/jor.1100090207
DO - 10.1002/jor.1100090207
M3 - Journal article
C2 - 1992069
VL - 9
SP - 191
EP - 202
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
SN - 0736-0266
IS - 2
ER -
ID: 244328263