82Rb and [15O]H2O myocardial perfusion PET imaging: a prospective head to head comparison
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82Rb and [15O]H2O myocardial perfusion PET imaging : a prospective head to head comparison. / Krakauer, Martin; Ismail, Afefah; Talleruphuus, Ulrik; Henriksen, Alexander Cuculiza; Lonsdale, Markus N.; Rasmussen, Inge Lise; Fuglsang, Stefan; Prescott, Eva; Hovind, Peter; Marner, Lisbeth.
In: Journal of Nuclear Cardiology, Vol. 30, No. 6, 2023, p. 2790-2802.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 82Rb and [15O]H2O myocardial perfusion PET imaging
T2 - a prospective head to head comparison
AU - Krakauer, Martin
AU - Ismail, Afefah
AU - Talleruphuus, Ulrik
AU - Henriksen, Alexander Cuculiza
AU - Lonsdale, Markus N.
AU - Rasmussen, Inge Lise
AU - Fuglsang, Stefan
AU - Prescott, Eva
AU - Hovind, Peter
AU - Marner, Lisbeth
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Background: 82Rb PET and [15O]H2O PET are both validated tracers for myocardical perfusion imaging but have not previously been compared clinically. During our site’s transition from 82Rb to [15O]H2O PET, we performed a head-to-head comparison in a mixed population with suspected ischemic heart disease. Methods: A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both 82Rb and [15O]H2O PET on the same day in rest and during adenosine-induced stress. The exams were rated by two blinded readers as normal, regional ischemia, globally reduced myocardial perfusion, or myocardial scarring. For [15O]H2O PET, regional ischemia was defined as two neighboring segments with average stress perfusion ≤ 2.3 mL/(min·g). Further, we evaluated a total perfusion deficit (TPD) of ≥ 10% as a more conservative marker of ischemia. Results: [15O]H2O PET identified more patients with regional ischemia: 17(46%) vs 9(24%), agreement: 59% corresponding to a Cohen’s kappa of.31 [95%CI.08-.53], (P < .001). Using the more conservative TPD ≥ 10%, the agreement increased to 86% corresponding to a kappa of.62 [95%CI.33-.92], (P = .001). For the subgroup of patients with no known heart disease (n = 18), the agreement was 94%. Interrater agreement was 95% corresponding to a kappa of.89 [95%CI.74-1.00] (P < .001). Conclusions: In clinical transition from 82Rb to [15O]H2O PET, it is important to take into account the higher frequency of patients with regional ischemia detected by [15O]H2O PET. Graphical Abstract: [Figure not available: see fulltext.].
AB - Background: 82Rb PET and [15O]H2O PET are both validated tracers for myocardical perfusion imaging but have not previously been compared clinically. During our site’s transition from 82Rb to [15O]H2O PET, we performed a head-to-head comparison in a mixed population with suspected ischemic heart disease. Methods: A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both 82Rb and [15O]H2O PET on the same day in rest and during adenosine-induced stress. The exams were rated by two blinded readers as normal, regional ischemia, globally reduced myocardial perfusion, or myocardial scarring. For [15O]H2O PET, regional ischemia was defined as two neighboring segments with average stress perfusion ≤ 2.3 mL/(min·g). Further, we evaluated a total perfusion deficit (TPD) of ≥ 10% as a more conservative marker of ischemia. Results: [15O]H2O PET identified more patients with regional ischemia: 17(46%) vs 9(24%), agreement: 59% corresponding to a Cohen’s kappa of.31 [95%CI.08-.53], (P < .001). Using the more conservative TPD ≥ 10%, the agreement increased to 86% corresponding to a kappa of.62 [95%CI.33-.92], (P = .001). For the subgroup of patients with no known heart disease (n = 18), the agreement was 94%. Interrater agreement was 95% corresponding to a kappa of.89 [95%CI.74-1.00] (P < .001). Conclusions: In clinical transition from 82Rb to [15O]H2O PET, it is important to take into account the higher frequency of patients with regional ischemia detected by [15O]H2O PET. Graphical Abstract: [Figure not available: see fulltext.].
KW - Cardiac imaging
KW - extraction fraction
KW - myocardial blood flow
KW - myocardial perfusion, HO
KW - positron emission tomography
KW - radiowater
U2 - 10.1007/s12350-023-03372-7
DO - 10.1007/s12350-023-03372-7
M3 - Journal article
C2 - 37789106
AN - SCOPUS:85173076488
VL - 30
SP - 2790
EP - 2802
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 6
ER -
ID: 379033440