Lars Ellgaard

Lars Ellgaard

Professor

ORCID: 0000-0002-7018-0137

Publication year:
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1 - 50 out of 64Page size: 50
  1. 2023
  2. Published

    A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3

    Hackney, Celeste Menuet, Flórez Salcedo, P., Mueller, E., Koch, Thomas Lund, Kjelgaard, L. D., Watkins, M., Zachariassen, L., Tuelund, P. S., McArthur, J. R., Adams, D. J., Kristensen, Anders Skov, Olivera, B., Finol-Urdaneta, R. K., Safavi-Hemami, H., Morth, J. P. & Ellgaard, Lars, 2023, In: PLOS Biology. 21, 8, 32 p., e3002217.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    A single-chain variable fragment selected against a conformational epitope of a recombinantly produced snake toxin using phage display

    Rimbault, C., Knudsen, P. D., Damsbo, A., Boddum, K., Ali, H., Hackney, Celeste Menuet, Ellgaard, Lars, Bohn, M. & Laustsen, A. H., 2023, In: New Biotechnology. 76, p. 23-32 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus

    Müller, E., Hackney, Celeste Menuet, Ellgaard, Lars & Morth, J. P., 2023, In: Acta crystallographica. Section F, Structural biology communications. 79, 9, p. 240-246 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2022
  6. Published

    Modern venomics - Current insights, novel methods, and future perspectives in biological and applied animal venom research

    von Reumont, B. M., Anderluh, G., Antunes, A., Ayvazyan, N., Beis, D., Caliskan, F., Crnković, A., Damm, M., Dutertre, S., Ellgaard, L., Gajski, G., German, H., Halassy, B., Hempel, B-F., Hucho, T., Igci, N., Ikonomopoulou, M. P., Karbat, I., Klapa, M. I., Koludarov, I. & 15 others, Kool, J., Lüddecke, T., Ben Mansour, R., Vittoria Modica, M., Moran, Y., Nalbantsoy, A., Ibáñez, M. E. P., Panagiotopoulos, A., Reuveny, E., Céspedes, J. S., Sombke, A., Surm, J. M., Undheim, E. A. B., Verdes, A. & Zancolli, G., 2022, In: GigaScience. 11, 27 p., giac048.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Production of an Active, Human Membrane Protein in Saccharomyces cerevisiae: Full-Length FICD

    Virolainen, M. S., Søltoft, C. L., Pedersen, Per Amstrup & Ellgaard, Lars, 2022, In: International Journal of Molecular Sciences. 23, 5, 17 p., 2458.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Strategies for Heterologous Expression, Synthesis, and Purification of Animal Venom Toxins

    Rivera-de-Torre, E., Rimbault, C., Jenkins, T. P., Sørensen, C. V., Damsbo, A., Saez, N. J., Duhoo, Y., Hackney, Celeste Menuet, Ellgaard, Lars & Laustsen, A. H., 2022, In: Frontiers in Bioengineering and Biotechnology. 9, 26 p., 811905.

    Research output: Contribution to journal › Review › Research › peer-review

  9. 2021
  10. Published

    DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system

    Bertelsen, A. B., Hackney, Celeste Menuet, Bayer, C. N., Kjelgaard, L. D., Rennig, M., Christensen, B., Sørensen, E. S., Safavi, Helena, Wulff, T., Ellgaard, Lars & Nørholm, M. H. H., 2021, In: Microbial Biotechnology. 14, 6, p. 2566-2580 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2020
  12. Published

    Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

    Bjørn-Yoshimoto, Walden, Ramiro, Iris Bea L. , Yandell, M., McIntosh, J. M., Olivera, B. M., Ellgaard, Lars & Safavi, Helena, 2020, In: Biomedicines. 8, 8, 22 p., 235.

    Research output: Contribution to journal › Review › Research › peer-review

  13. 2019
  14. Published

    Cellular functions and molecular mechanisms of non-lysine ubiquitination

    McClellan, A. J., Laugesen, Sophie Heiden & Ellgaard, Lars, 2019, In: Open Biology. 9, 9, 16 p., 190147.

    Research output: Contribution to journal › Review › Research › peer-review

  15. Published

    The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

    Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. 2018
  17. Published

    How are proteins reduced in the endoplasmic reticulum?

    Ellgaard, Lars, Sevier, C. S. & Bulleid, N. J., Jan 2018, In: Trends in Biochemical Sciences. 43, 1, p. 32-43 12 p.

    Research output: Contribution to journal › Review › Research › peer-review

  18. Published

    Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

    O'Brien, H., Kanemura, S., Okumura, M., Baskin, R. P., Bandyopadhyay, P. K., Olivera, B. M., Ellgaard, Lars, Inaba, K. & Safavi, Helena, 2018, In: International Journal of Molecular Sciences . 19, 11, 15 p., 3418.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Evolutionary Adaptations to Cysteine-rich Peptide Folding

    Safavi, Helena, Foged, M. M. & Ellgaard, Lars, 2018, Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering . Feige, M. J. (ed.). Royal Society of Chemistry, p. 99-128 30 p. (Chemical Biology, Vol. 9).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  20. 2016
  21. Published

    Co- and post-translational protein folding in the ER

    Ellgaard, Lars, McCaul, N., Chatsisvili, A. & Braakman, I., Jun 2016, In: Traffic (Malden). 17 , 6, p. 615-638 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    Boomsma, Wouter, Nielsen, S. V., Lindorff-Larsen, Kresten, Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2016, In: PeerJ. 4, 18 p., e1725.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

    Timms, R. T., Menzies, S. A., Tchasovnikarova, I. A., Christensen, L. C., Williamson, J. C., Antrobus, R., Dougan, G., Ellgaard, Lars & Lehner, P. J., 2016, In: Nature Communications. 7, 10 p., 11786.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides

    Safavi, Helena, Li, Q., Jackson, R. L., Song, A. S., Boomsma, Wouter, Bandyopadhyay, P. K., Gruber, C. W., Purcell, A. W., Yandell, M., Olivera, B. M. & Ellgaard, Lars, 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 12, p. 3227-3232 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2015
  26. Published

    Specialized insulin is used for chemical warfare by fish-hunting cone snails

    Safavi, Helena, Gajewiak, J., Karanth, S., Robinson, S. D., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, Lars & Olivera, B. M., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 6, p. 1743-1748 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2014
  28. Published

    Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

    Hansen, H. G., Søltoft, C. L., Schmidt, J. D., Birk, J., Appenzeller-Herzog, C. & Ellgaard, Lars, 2014, In: Bioscience Reports. 34, 2, 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

    Ramming, T., Hansen, H. G., Nagata, K., Ellgaard, Lars & Appenzeller-Herzog, C., 2014, In: Free Radical Biology & Medicine. 70, p. 106-116 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Giftsnegle som medicinskabe

    Safavi, Helena, Andersen, K. M. & Ellgaard, Lars, 2014, In: Aktuel Naturvidenskab. 2014, 2, p. 12-16 5 p.

    Research output: Contribution to journal › Journal article › Research

  31. Published

    The selenium metabolite methylselenol regulates the expression of ligands that trigger immune activation through the lymphocyte receptor NKG2D

    Hagemann-Jensen, M. H., Uhlenbrock, F. K., Kehlet, S., Andresen, Lars, Gabel-Jensen, C., Ellgaard, Lars, Gammelgaard, Bente & Skov, Søren, 2014, In: The Journal of Biological Chemistry. 289, p. 31576-31590 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2012
  33. Published

    HUWE1 and TRIP12 Collaborate in Degradation of Ubiquitin-Fusion Proteins and Misframed Ubiquitin

    Poulsen, E. G., Steinhauer, C., Lees, M., Lauridsen, A., Ellgaard, Lars & Hartmann-Petersen, Rasmus, 2012, In: P L o S One. 7, 11, 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Hyperactivity of the Ero1α oxidase elicits endoplasmic reticulum stress but no broad antioxidant response

    Hansen, H. G., Schmidt, J. D., Søltoft, C. L., Ramming, T., Geertz-Hansen, H. M., Christensen, B., Sørensen, E. S., Juncker, A., Appenzeller, C. A. & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 47, p. 39513-39523 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

    Kriegenburg, F., Ellgaard, Lars & Hartmann-Petersen, Rasmus, 2012, In: F E B S Journal. 279, 4, p. 532-542 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

    Lynes, E. M., Bui, M., Yap, M. C., Benson, M. D., Schneider, B., Ellgaard, Lars, Berthiaume, L. G. & Simmen, T., 2012, In: E M B O Journal. 31, 2, p. 457-470 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region

    Christensen, L. C., Jensen, N. W., Lages Lino Vala, A., Kamarauskaite, J., Johansson, L. C., Winther, Jakob R., Hofmann, K., Teilum, Kaare & Ellgaard, Lars, 2012, In: Journal of Biological Chemistry. 287, 31, p. 26388-26399 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2011
  39. Published

    Identification of the PDI-family member ERp90 as an interaction partner of ERFAD

    Riemer, J., Hansen, H. G., Appenzeller-Herzog, C., Appenzeller-Herzog, C., Johansson, L. & Ellgaard, Lars, 2011, In: P L o S One. 6, 2, 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Multiple ways to make disulfides

    Bulleid, N. J. & Ellgaard, Lars, 2011, In: Trends in Biochemical Sciences. 36, 9, p. 485-92 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. 2010
  42. Published

    Disulphide production by Ero1a-PDI relay is rapid and effectively regulated

    Appenzeller-Herzog, C., Riemer, J., Zito, E., Chin, K., Ron, D., Spiess, M. & Ellgaard, Lars, 6 Oct 2010, In: EMBO Journal. 29, 19, p. 3318-29 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    A di-arginine motif contributes to the ER localization of the type I transmembrane ER oxidoreductase TMX4

    Roth, D., Lynes, E., Riemer, J., Hansen, H. G., Althaus, N., Simmen, T. & Ellgaard, Lars, 2010, In: Biochemical Journal. 425, 1, p. 195-205 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    A male with unilateral microphthalmia reveals a role for TMX3 in eye development

    Chao, R., Nevin, L., Agarwal, P., Riemer, J., Bai, X., Delaney, A., Akana, M., JimenezLopez, N., Bardakjian, T., Schneider, A., Chassaing, N., Schorderet, D. F., FitzPatrick, D., Kwok, P., Ellgaard, Lars, Gould, D. B., Zhang, Y., Malicki, J., Baier, H. & Slavotinek, A., 2010, In: PLoS ONE. 5, 5, p. e10565 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Disulphide production by Ero1α-PDI relay is rapid and effectively regulated

    Appenzeller-Herzog, C., Riemer, J., Zito, E., Chin, K., Ron, D., Spiess, M. & Ellgaard, Lars, 2010, In: EMBO Journal. 29, 19, p. 3318-3329

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2009
  47. Published

    A luminal flavoprotein in endoplasmic reticulum-associated degradation

    Riemer, J., Appenzeller-Herzog, C., Johansson, L., Bodenmiller, B., Hartmann-Petersen, Rasmus & Ellgaard, Lars, 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 35, p. 14831-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. 2008
  49. Published

    A novel disulphide switch mechanism in Ero1 balances ER oxidation in human cells

    Appenzeller-Herzog, C., Riemer, J., Christensen, B., Sørensen, E. B. & Ellgaard, Lars, 2008, In: EMBO Journal. 27, p. 2977–2987

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

    Appenzeller-Herzog, C., Riemer, J., Christensen, B., Sørensen, E. S. & Ellgaard, Lars, 2008, In: EMBO Journal. 27, 22, p. 2977-2987

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    In vivo reduction-oxidation state of protein disulfide isomerase: the two active sites independently occur in the reduced and oxidized forms

    Appenzeller-Herzog, C. & Ellgaard, Lars, 2008, In: Antioxidants & Redox Signaling. 10, 1, p. 55-64 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. 2007
  53. Published

    Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells.

    Schelhaas, M., Malmström, J., Pelkmans, L., Haugstetter, J., Ellgaard, Lars, Grünewald, K. & Helenius, A., 2007, In: Cell. 131, 3, p. 516-29 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Structure-Function Analysis of the Endoplasmic Reticulum Oxidoreductase TMX3 Reveals Interdomain Stabilization of the N-terminal Redox-active Domain

    Haugstetter, J., Maurer, M. A., Blicher, T., Pagac, M., Wider, G. & Ellgaard, Lars, 2007, In: Journal of Biological Chemistry. 282, 46, p. 33859-33867

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Structure-function analysis of the ER oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain

    Haugstetter, J., Michael, M., Blicher, T., Pagac, M., Wider, G. & Ellgaard, Lars, 2007, In: Journal of Biological Chemistry. 280, 46, p. 33859-33867

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    The human PDI family: Versatility packed into a single fold.

    Ellgaard, Lars & Ellgaard, Lars, 2007, In: BBA General Subjects.

    Research output: Contribution to journal › Review › Research › peer-review

  57. 2006
  58. Published

    Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.

    Kulp, M. S., Frickel, E. M., Ellgaard, Lars & Weismann, J. S., 2006, In: Journal of Biological Chemistry. 281, 2, p. 876-84.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. 2005

  60. The human protein disulphide isomerase family: substrate interactions and functional properties

    Ellgaard, Lars & Ruddock, L. W., 2005, In: EMBO Reports. 6, 1, p. 28-32

    Research output: Contribution to journal › Review › Research › peer-review

  61. 2004

  62. Catalysis of disulphide bond formation in the endoplasmic reticulum

    Ellgaard, Lars, 2004, In: Biochemical Society Transactions. 32, 5, p. 663-667

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase

    Frickel, E., Frei, P., Bouvier, M., Stafford, W. F., Helenius, A., Glockshuber, R. & Ellgaard, Lars, 2004, In: Journal of Biological Chemistry. 279, 18, p. 18277-18287

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Mutational Analysis Provides Molecular Insight into the Carbohydrate-Binding Region of Calreticulin: Pivotal Roles of Tyrosine-109 and Aspartate-135 in Carbohydrate Recognition

    Kapoor, M., Ellgaard, Lars, Gopalakrishnapai, J., Schirra, C., Gemma, E., Oscarson, S., Helenius, A. & Surolia, A., 2004, In: Biochemistry. 43, 1, p. 97-106

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. 2003

  66. Calnexin, calreticulin, and ERp57: Teammates in glycoprotein folding

    Ellgaard, Lars & Frickel, E., 2003, In: Cell Biochemistry and Biophysics. 39, 3, p. 223-247

    Research output: Contribution to journal › Review › Research › peer-review

  67. Interactions of Substrate with Calreticulin, an Endoplasmic Reticulum Chaperone

    Kapoor, M., Srinivas, H., Kandiah, E., Gemma, E., Ellgaard, Lars, Oscarson, S., Helenius, A. & Surolia, A., 2003, In: Journal of Biological Chemistry. 278, 8, p. 6194-6200

    Research output: Contribution to journal › Journal article › Research › peer-review

  68. 2002

  69. NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain

    Ellgaard, Lars, Bettendorff, P., Braun, D., Herrmann, T., Fiorito, F., Jelesarov, I., Güntert, P., Helenius, A. & Wüthrich, K., 2002, In: Journal of Molecular Biology. 322, 4, p. 773-784

    Research output: Contribution to journal › Journal article › Research › peer-review

  70. TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain

    Frickel, E., Riek, R., Jelesarov, I., Helenius, A., Wüthrich, K. & Ellgaard, Lars, 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 1954-1959

    Research output: Contribution to journal › Journal article › Research › peer-review

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