Cord Herbert Brakebusch
Department of Biomedical Sciences
Blegdamsvej 3
2200 København N
- 2024
- Published
Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entry
Bock, F., Dong, X., Li, S., Viquez, O. M., Sha, E., Tantengco, M., Hennen, E. M., Plosa, E., Ramezani, A., Brown, K. L., Whang, Y. M., Terker, A. S., Arroyo, J. P., Harrison, D. G., Fogo, A., Brakebusch, Cord Herbert, Pozzi, A. & Zent, R., 2024, In: Science Advances. 10, 6, eadi7840.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination
Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2023, In: Progress in Neurobiology. 227, 13 p., 102481.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Martínez-Sánchez, L. D. C., Ngo, P. A., Pradhan, R., Becker, L-S., Boehringer, D., Soteriou, D., Kubankova, M., Schweitzer, C., Koch, T., Thonn, V., Erkert, L., Stolzer, I., Günther, C., Becker, C., Weigmann, B., Klewer, M., Daniel, C., Amann, K., Tenzer, S., Atreya, R. & 8 others, , 2023, In: Gut. 72, 2, p. 275-294 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance
Socodato, R., Almeida, T. O., Portugal, C. C., Santos, E. C. S., Tedim-Moreira, J., Galvão-Ferreira, J., Canedo, T., Baptista, F. I., Magalhães, A., Ambrósio, A. F., Brakebusch, Cord Herbert, Rubinstein, B., Moreira, I. S., Summavielle, T., Pinto, I. M. & Relvas, J. B., 2023, In: Cell Reports. 42, 12, 28 p., 113447.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoB promotes Salmonella survival by regulating autophagy
Kirchenwitz, M., Halfen, J., von Peinen, K., Prettin, S., Kollasser, J., zur Lage, S., Blankenfeldt, W., Brakebusch, Cord Herbert, Rottner, K., Steffen, A. & Stradal, T. E. B., 2023, In: European Journal of Cell Biology. 102, 4, 17 p., 151358.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoB promotesSalmonellasurvival by regulating autophagy
Kirchenwitz, M., Halfen, J., Peinen, K. V., Prettin, S., Kollasser, J., Brakebusch, Cord Herbert, Rottner, K., Steffen, A. & Stradal, T. E. B., 2023, bioRxiv, 52 p.Research output: Working paper › Preprint › Research
- Published
Two Transient Receptor Potential Channels at Focal Adhesions
Mitsou, I., Carlson, C. R., Multhaupt, Hinke Arnolda B V H, Brakebusch, Cord Herbert & Couchman, John Robert, 2023, In: Journal of Histochemistry and Cytochemistry. 71, 9, p. 495-508 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivo
Herum, K. M., Weng, Guangzheng, Kahnert, Konstantin, Waikel, R., Milburn, G., Conger, A., Anaya, P., Campbell, K. S., Lundby, Alicia, Won, K. J. & Brakebusch, Cord Herbert, 2022, In: Matrix Biology Plus. 15, 100113.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of TGF-β signaling in a human organotypic skin model reveals that loss of TGF-βRII induces invasive tissue growth
Ye, Z., Kilic, G., Dabelsteen, Sally, Marinova, I. N., Thøfner, J. F. B., Song, Ming, Levann, Asha Maria Rudjord, Bagdonaite, Ieva , Vakhrushev, Sergey, Brakebusch, Cord Herbert, Olsen, Jesper Velgaard & Wandall, Hans H., 2022, In: Science Signaling. 15, 761, eabo2206.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination
Seixas, A. I., Morais, M. R. G., Brakebusch, Cord Herbert & Relvas, J. B., 2022, Cold Spring Harbor Laboratory, 15 p. (bioRxiv).Research output: Working paper › Preprint › Research
- Published
The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition
Petersen, L., Stroh, S., Schöttelndreier, D., Grassl, G. A., Rottner, K., Brakebusch, Cord Herbert, Fahrer, J. & Genth, H., 2022, In: Frontiers in Microbiology. 13, 11 p., 846215.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells
Vadakumchery, A., Faraidun, H., Ayoubi, O. E., Outaleb, I., Schmid, V., Abdelrasoul, H., Amendt, T., Khadour, A., Setz, C., Göhring, K., Lodd, K., Hitzing, C., Alkhatib, A., Bilal, M., Benckendorff, J., Al Shugri, A. K., Brakebusch, C. H., Engels, N., Datta, M., Hobeika, E. & 2 others, , 2022, In: Frontiers in Immunology. 13, 19 p., 842340.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation
Brandao, R., Kwa, M. Q., Yarden, Y. & Brakebusch, Cord Herbert, 2021, In: FEBS Open Bio. 11, 6, p. 1579-1592 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells
Xu, L., Zu, T., Li, T., Li, M., Mi, J., Bai, F., Liu, G., Wen, J., Li, H., Brakebusch, Cord Herbert, Wang, X. & Wu, X., 2021, In: PLOS Genetics. 17, 2, p. 1-25 e1009283.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analyzing skin tumor development in mice by the DMBA/TPA model
Li, H. & Brakebusch, Cord Herbert, 2021, Carcinogen-driven mouse models of oncogenesis. Galluzzi, L. & Buqué, A. (eds.). Elsevier, Vol. 163. p. 113-121 9 p. (Methods in Cell Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
CRISPR Genome Editing: How to Make a Fantastic Method Even Better
Brakebusch, Cord Herbert, 2021, In: Cells. 10, 2, p. 1-2 408.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model
Kwa, M. Q., Brandao, R., Phung, T. H., Ge, J., Scieri, G. & Brakebusch, Cord Herbert, 2021, In: Cells. 10, 4, 942.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity
Bock, F., Elias, B. C., Dong, X., Parekh, D. V., Mernaugh, G., Viquez, O. M., Hassan, A., Amara, V. R., Liu, J., Brown, K. L., Terker, A. S., Chiusa, M., Gewin, L. S., Fogo, A. B., Brakebusch, Cord Herbert, Pozzi, A. & Zent, R., 2021, In: Journal of Cell Biology. 220, 11, 28 p., e202103080.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPase Signaling in Health and Disease: A Complex Signaling Network
Brakebusch, Cord Herbert, 2021, In: Cells. 10, 2, p. 1-3 401.Research output: Contribution to journal › Editorial › Research › peer-review
- Published
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
Stern, S., Hilton, B. J., Burnside, E. R., Dupraz, S., Handley, E. E., Gonyer, J. M., Brakebusch, Cord Herbert & Bradke, F., 2021, In: Neuron. 109, 21, p. 3436-3455 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes
Heib, T., Hermanns, H. M., Manukjan, G., Englert, M., Kusch, C., Becker, I. C., Gerber, A., Wackerbarth, L. M., Burkard, P., Dandekar, T., Balkenhol, J., Jahn, D., Beck, S., Meub, M., Dütting, S., Stigloher, C., Sauer, M., Cherpokova, D., Schulze, H., Brakebusch, C. & 3 others, , 2021, In: Cell Reports. 35, 6, p. 109102 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Improving Precise CRISPR Genome Editing by Small Molecules: Is there a Magic Potion?
Bischoff, N., Wimberger, S., Maresca, M. & Brakebusch, Cord Herbert, 2020, In: Cells. 9, 5Research output: Contribution to journal › Review › Research › peer-review
- Published
Maintaining resting cardiac fibroblasts in vitro by disrupting mechanotransduction
Gilles, G., McCulloch, A. D., Brakebusch, Cord Herbert & Herum, K. M., 2020, In: PLoS ONE. 15, 10, p. 1-13 e0241390.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration
Socodato, R., Portugal, C. C., Canedo, T., Rodrigues, A., Almeida, T. O., Henriques, J. F., Vaz, S. H., Magalhães, J., Silva, C. M., Baptista, F. I., Alves, R. L., Coelho-Santos, V., Silva, A. P., Paes-de-Carvalho, R., Magalhães, A., Brakebusch, Cord Herbert, Sebastião, A. M., Summavielle, T., Ambrósio, A. F. & Relvas, J. B., 2020, In: Cell Reports. 31, 12, p. 1-29 107796.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PATHBIO: an international training program for precision mouse phenotyping
Ruberte, J., Schofield, P. N., Brakebusch, Cord Herbert, Vogel, P., Herault, Y., Gracia, G., McKerlie, C., Hrabĕ de Angelis, M., Hagn, M. & Sundberg, J. P., 2020, In: Mammalian Genome. 31, p. 49-53Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
Herum, K. M., Romaine, A., Wang, A., Melleby, A. O., Strand, M. E., Pacheco, J., Braathen, B., Dunér, P., Tønnessen, T., Lunde, I. G., Sjaastad, I., Brakebusch, Cord Herbert, McCulloch, A. D., Gomez, M. F., Carlson, C. R. & Christensen, G., 2020, In: Journal of the American Heart Association. 9, 3, 31 p., e013518.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway
Zu, T., Wen, J., Xu, L., Li, H., Mi, J., Brakebusch, Cord Herbert, Fisher, D. E. & Wu, X., 2020, In: Frontiers in Oncology. 10, 15 p., 624.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Author Correction: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 26 Nov 2019, In: Scientific Reports. 9, 1, p. 18008 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
RhoA Controls Axon Extension Independent of Specification in the Developing Brain
Dupraz, S., Hilton, B. J., Husch, A., Santos, T. E., Coles, C. H., Stern, S., Brakebusch, Cord Herbert & Bradke, F., 18 Nov 2019, In: Current biology : CB. 29, 22, p. 3874-3886 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
López-Posadas, R., Fastancz, P., Martínez-Sánchez, L. D. C., Panteleev-Ivlev, J., Thonn, V., Kisseleva, T., Becker, L. S., Schulz-Kuhnt, A., Zundler, S., Wirtz, S., Atreya, R., Carlé, B., Friedrich, O., Schürmann, S., Waldner, M. J., Neufert, C., Brakebusch, Cord Herbert, Bergö, M. O., Neurath, M. F. & Atreya, I., Nov 2019, In: Gastroenterology. 157, 5, p. 1293-1309 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Akula, M. K., Ibrahim, M. X., Ivarsson, E. G., Khan, O. M., Kumar, I. T., Erlandsson, M., Karlsson, C., Xu, X., Brisslert, M., Brakebusch, Cord Herbert, Wang, D., Bokarewa, M., Sayin, V. I. & Bergo, M. O., 4 Sep 2019, In: Nature Communications. 10, 1, p. 1-13 13 p., 3975.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Senescence regulation by nuclear N-WASP: a role in cancer?
Li, H. & Brakebusch, Cord Herbert, Jul 2019, In: Oncoscience. 6, 7-8, p. 354-356 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Negative regulation of p53-induced senescence by N-WASP is crucial for DMBA/TPA-induced skin tumor formation
Li, H., Petersen, S., Garcia Mariscal, A. & Brakebusch, Cord Herbert, 1 May 2019, In: Cancer Research. 79, 9, p. 2167-2181 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adgrf5 contributes to patterning of the endothelial deep layer in retina
Niaudet, C., Petkova, M., Jung, B., Lu, S., Laviña, B., Offermanns, S., Brakebusch, Cord Herbert & Betsholtz, C., 2019, In: Angiogenesis. 22, 4, p. 491-505 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection
Papareddy, P., Rossnagel, M., Doreen Hollwedel, F., Kilic, G., Veerla, S., Naudin, C., Smeds, E., Westman, J., Martinez-Martinez, I., Egesten, A., de la Morena-Barrio, M. E., Corral, J., Linder, A., Artoni, A., Abbattista, M., Novembrino, C., Brakebusch, Cord Herbert, Martinelli, I., Kasetty, G. & Herwald, H., 2019, In: Nature Microbiology. 4, 12, p. 2442-2455 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
Castro, M., Laviña, B., Ando, K., Álvarez-Aznar, A., Abu Taha, A., Brakebusch, Cord Herbert, Dejana, E., Betsholtz, C. & Gaengel, K. B., 2019, In: Circulation Research. 124, 8, p. 1240-1252 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M. & Brakebusch, Cord Herbert, 2019, In: Clinical and Experimental Metastasis. 36, 2, p. 71-86Research output: Contribution to journal › Review › Research › peer-review
- Published
Rho GTPases in cancer: friend or foe?
Svensmark, J. H. & Brakebusch, Cord Herbert, 2019, In: Oncogene. 38, p. 7448-7456Research output: Contribution to journal › Review › Research › peer-review
- Published
RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones
Skov, Louise Julie, Ratner, C., Hansen, Nikolaj Winther, Thompson, J. J., Egerod, Kristoffer Lihme, Burm, Hayley Beth, Dalbøge, L. S., Hedegaard, M. A., Brakebusch, Cord Herbert, Pers, Tune H, Perrier, Jean-Francois Marie & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7, 13 p., UNSP e12761.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells
Cavaco, A. C. M., Rezaei, M., Caliandro, M. F., Lima, A. M., Stehling, M., Dhayat, S. A., Haier, J., Brakebusch, Cord Herbert & Eble, J. A., 2019, In: Cancers. 11, 1, p. 1-20 20 p., 14.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small GTPase RhoA regulates the onset of myelination and myelin production during PNS development: [Meeting Abstract}
Seixas, A., Morais, M., Pereira, J. A., Krause, S., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2019, In: Glia. 67, S1, p. E473-E474 T12-052B.Research output: Contribution to journal › Conference abstract in journal › Research
- 2018
- Published
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
Laviña, B., Castro, M., Niaudet, C., Cruys, B., Álvarez-Aznar, A., Carmeliet, P., Bentley, K., Brakebusch, Cord Herbert, Betsholtz, C. & Gaengel, K., 2 Jul 2018, In: Development (Cambridge, England). 145, 13, 20 p., dev161182.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
García-Mariscal, A., Li, H., Pedersen, E., Peyrollier, K., Ryan, K. M., Stanley, A., Quondamatteo, F. & Brakebusch, Cord Herbert, 15 Feb 2018, In: Oncogene. 37, 7, p. 847-860 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines
Martin Gonzalez, Javier, Baudet, A., Abelechian, Sahar, Bonderup, K., d'Altri, T., Porse, Bo Torben, Brakebusch, Cord Herbert, Juliusson, G. & Cammenga, J., 2018, In: Genesis: The Journal of Genetics and Development (Print). 56, 9, p. 1-7 7 p., e23238.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
Li, H., Yao, Q., Mariscal, A. G., Wu, X., Hülse, J., Pedersen, E., Helin, K., Waisman, A., Vinkel, C., Thomsen, Simon Francis, Avgustinova, A., Benitah, S. A., Lovato, P., Norsgaard, H., Mortensen, M. S., Veng, L., Rozell, B. & Brakebusch, Cord Herbert, 2018, In: Nature Communications. 9, 1, p. 1-18 18 p., 1420.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke
Karabiyik, C., Fernandes, R., Figueiredo, F. R., Socodato, R., Brakebusch, Cord Herbert, Lambertsen, K. L., Relvas, J. B. & Santos, S. D., 2018, In: Brain Pathology. 28, 4, p. 569-580 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA Controls Retinoid Signaling by ROCK Dependent Regulation of Retinol Metabolism
García-Mariscal, A., Peyrollier, K., Basse, A., Pedersen, E. D. K., Rühl, R., van Hengel, J. & Brakebusch, Cord Herbert, 2018, In: Small GTPases. 9, 5, p. 433–444Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis
Manresa-Arraut, A., Johansen, F. F., Brakebusch, Cord Herbert, Issazadeh-Navikas, Shohreh & Hasseldam, Henrik, 2018, In: Frontiers in Immunology. 9, p. 1-14 14 p., 1235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells
Ge, J., Burnier, L., Adamopoulou, M., Kwa, M. Q., Schaks, M., Rottner, K. & Brakebusch, Cord Herbert, 2018, In: The Journal of Biological Chemistry. 293, 24, p. 9358-9369 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42
Kage, F., Steffen, A., Ellinger, A., Ranftler, C., Gehre, C., Brakebusch, Cord Herbert, Pavelka, M., Stradal, T. & Rottner, K., 1 Dec 2017, In: Scientific Reports. 7, 1, 17 p., 9791.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
Dütting, S., Gaits-Iacovoni, F., Stegner, D., Popp, M., Antkowiak, A., Van Eeuwijk, J. M. M., Nurden, P., Stritt, S., Heib, T., Aurbach, K., Angay, O., Cherpokova, D., Heinz, N., Baig, A. A., Gorelashvili, M. G., Gerner, F., Heinze, K. G., Ware, J., Krohne, G., Ruggeri, Z. M. & 6 others, , 15 Jun 2017, In: Nature Communications. 8, 13 p., 15838.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FMNL formins boost lamellipodial force generation
Kage, F., Winterhoff, M., Dimchev, V., Mueller, J., Thalheim, T., Freise, A., Brühmann, S., Kollasser, J., Block, J., Dimchev, G. A., Geyer, M., Schnittler, H., Brakebusch, Cord Herbert, Stradal, T. E. B., Carlier, M., Sixt, M., Käs, J., Faix, J. & Rottner, K., 22 Mar 2017, In: Nature Communications. 8, 16 p., 14832.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin
Woodham, E. F., Paul, N. R., Tyrrell, B., Spence, H. J., Swaminathan, K., Scribner, M. R., Giampazolias, E., Hedley, A., Clark, W., Kage, F., Marston, D. J., Hahn, K. M., Tait, S. W. G., Larue, L., Brakebusch, Cord Herbert, Insall, R. H. & Machesky, L. M., 6 Mar 2017, In: Current biology : CB. 27, 5, p. 624-637 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate
Wahlestedt, M., Erlandsson, E., Kristiansen, T., Lu, R., Brakebusch, Cord Herbert, Weissman, I. L., Yuan, J., Martin Gonzalez, Javier & Bryder, D., 22 Feb 2017, In: Nature Communications. 8, 8 p., 14533.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytoskeletal stability in the auditory organ in vivo: RhoA is dispensable for wound healing but essential for hair cell development
Anttonen, T., Belevich, I., Laos, M., Herranen, A., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2017, In: eNeuro. 4, 5, 17 p., e0149-17.2017.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
Martin Gonzalez, Javier, Morgani, S. M., Bone, Robert Alexander, Bonderup, K., Abelechian, Sahar, Brakebusch, Cord Herbert & Brickman, Joshua Mark, 9 Aug 2016, In: Stem Cell Reports. 7, 2, p. 177-91 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in dermal matrix in the absence of Rac1 in keratinocytes
Stanley, A., Pedersen, E. D. K., Brakebusch, Cord Herbert & Quondamatteo, F., May 2016, In: Journal of Anatomy. 228, 5, p. 826-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice
Choudhari, R., Minero, V. G., Menotti, M., Pulito, R., Brakebusch, Cord Herbert, Compagno, M., Voena, C., Ambrogio, C. & Chiarle, R., 10 Mar 2016, In: Blood. 127, 10, p. 1297-306 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation
López-Posadas, R., Becker, C., Günther, C., Tenzer, S., Amann, K., Billmeier, U., Atreya, R., Fiorino, G., Vetrano, S., Danese, S., Ekici, A. B., Wirtz, S., Thonn, V., Watson, A. J. M., Brakebusch, Cord Herbert, Bergö, M., Neurath, M. F. & Atreya, I., Feb 2016, In: The Journal of Clinical Investigation. 126, 2, p. 611-26 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development
Elias, B. C., Das, A., Parekh, D. V., Mernaugh, G., Adams, R., Yang, Z., Brakebusch, Cord Herbert, Pozzi, A., Marciano, D. K., Carroll, T. J. & Zent, R., 1 Dec 2015, In: Journal of Cell Science. 128, 23, p. 4293-305 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells
Schulz, A. M., Stutte, S., Hogl, S., Luckashenak, N., Dudziak, D., Leroy, C., Forné, I., Imhof, A., Müller, S. A., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 9 Nov 2015, In: Journal of Cell Biology. 211, 3, p. 553-67 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA
Li, S., Dislich, B., Brakebusch, Cord Herbert, Lichtenthaler, S. F. & Brocker, T., 1 Nov 2015, In: Journal of immunology (Baltimore, Md. : 1950). 195, 9, p. 4244-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cofilin phosphorylation is elevated after F-actin disassembly induced by Rac1 depletion
Liu, L., Li, J., Zhang, L., Zhang, F., Zhang, R., Chen, X., Brakebusch, Cord Herbert, Wang, Z. & Liu, X., 27 Oct 2015, In: BioFactors (Oxford, England). 41, 5, p. 352-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets
Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S., Ahmadian, M. R., Brakebusch, Cord Herbert & Nieswandt, B., May 2015, In: Journal of Thrombosis and Haemostasis. 13, 5, p. 827-38 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair
Xia, J., Swiercz, J. M., Bañón-Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, Cord Herbert, Kumanogoh, A., Friedel, R. H., Martín-Belmonte, F., Gröne, H., Offermanns, S. & Worzfeld, T., May 2015, In: Developmental Cell. 33, 3, p. 299-313 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community
Meehan, T. F., Chen, C. K., Koscielny, G., Relac, M., Wilkinson, P., Flicek, P., Parkinson, H., Bottomley, J., Ramirez-Solis, R., Smedley, D., Castro, A., Fessele, S., Steinkamp, R., Hagn, M., Raess, M., De Angelis, M. H., Ball, S., Blake, A., Fray, M., Kenyon, J. & 23 others, , 28 Jan 2015, In: Nucleic Acids Research. 43, D1, p. D1171-D1175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity
Burbage, M., Keppler, S. J., Gasparrini, F., Martínez-Martín, N., Gaya, M., Feest, C., Domart, M., Brakebusch, Cord Herbert, Collinson, L., Bruckbauer, A. & Batista, F. D., 2015, In: The Journal of Experimental Medicine. 212, 1, p. 53-72Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Mouse macrophages completely lacking Rho (RhoA, RhoB and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and increased motility
Koenigs, V., Jennings, R., Vogl, T., Horsthemke, M., Bachg, A. C., Xu, Y., Grobe, K., Brakebusch, Cord Herbert, Schwab, A., Baehler, M., Knaus, U. G. & Hanley, P. J., 31 Oct 2014, In: The Journal of Biological Chemistry. 289, 44, p. 30772-30784 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How to Bury the Dead: Elimination of Apoptotic Hair Cells from the Hearing Organ of the Mouse
Anttonen, T., Belevich, I., Kirjavainen, A., Laos, M., Brakebusch, Cord Herbert, Jokitalo, E. & Pirvola, U., 30 Jul 2014, In: J A R O. 15, 6, p. 975-992 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1-dependent recruitment of PAK2 to G 2 phase centrosomes and their roles in the regulation of mitotic entry
May, M., Schelle, I., Brakebusch, Cord Herbert, Rottner, K. & Genth, H., 19 May 2014, In: Cell Cycle. 13, 14, p. 2211-21 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and rho GTPases in cell migration
Stanley, A., Thompson, K., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., 1 May 2014, In: Antioxidants & Redox Signaling. 20, 13, p. 2026-42 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness
Jennings, R. T., Strengert, M., Hayes, P., El-Benna, J., Brakebusch, Cord Herbert, Kubica, M. & Knaus, U. G., 29 Apr 2014, In: Blood. 123, 23, p. 3635-45 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small GTPase Rac1 is required for smooth muscle contraction
Rahman, A., Davis, B., Lövdahl, C., Hanumaiah, V. T., Feil, R., Brakebusch, Cord Herbert & Arner, A., 1 Mar 2014, In: The Journal of Physiology. 592, 5, p. 915-26 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPases and cancer
Li, H., Peyrollier, K., Kilic, G. & Brakebusch, Cord Herbert, Mar 2014, In: BioFactors (Oxford, England). 40, 2, p. 226-35 10 p.Research output: Contribution to journal › Review › Research › peer-review
- 2013
- Published
Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes
Wang, Z., Jiang, Z., Zhang, Q., Hu, M., Huang, L., Ou, X., Guo, L., Ouyang, Y., Hou, Y., Brakebusch, Cord Herbert, Schatten, H. & Sun, Q., Dec 2013, In: Molecular Biology of the Cell. 24, 24, p. 3832-41 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42
Pleines, I., Dütting, S., Cherpokova, D., Eckly, A., Meyer, I., Morowski, M., Krohne, G., Schulze, H., Gachet, C., Debili, N., Brakebusch, Cord Herbert & Nieswandt, B., 31 Oct 2013, In: Blood. 122, 18, p. 3178-87 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation
Steffen, A., Ladwein, M., Dimchev, G. A., Hein, A., Schwenkmezger, L., Arens, S., Ladwein, K. I., Margit Holleboom, J., Schur, F., Victor Small, J., Schwarz, J., Gerhard, R., Faix, J., Stradal, T. E. B., Brakebusch, Cord Herbert & Rottner, K., 15 Oct 2013, In: Journal of Cell Science. 126, Pt 20, p. 4572-88 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Huelsenbeck, S. C., Roggenkamp, D., May, M., Huelsenbeck, J., Brakebusch, Cord Herbert, Rottner, K., Ladwein, M., Just, I., Fritz, G., Schmidt, G. & Genth, H., Aug 2013, In: International Journal of Biochemistry & Cell Biology. 45, 8, p. 1767-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuronal Rac1 is required for learning-evoked neurogenesis
Haditsch, U., Anderson, M. P., Freewoman, J., Cord, B., Babu, H., Brakebusch, Cord Herbert & Palmer, T. D., 24 Jul 2013, In: Journal of Neuroscience. 33, 30, p. 12229-41 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 promotes host defenses against fatal infection
Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Baldwin, H. S., Brakebusch, Cord Herbert, Skaar, E. P., Boothby, M. & Zent, R., 20 May 2013, In: Infection and Immunity. 81, 8, p. 2714-2723 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
Blattner, S. M., Hodgin, J. B., Nishio, M., Wylie, S. A., Saha, J., Soofi, A. A., Vining, C., Randolph, A., Herbach, N., Wanke, R., Atkins, K. B., Gyung Kang, H., Henger, A., Brakebusch, Cord Herbert, Holzman, L. B. & Kretzler, M., 15 May 2013, In: Kidney International.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
p21-activated Kinase1(PAK1) can promote ERK activation in a kinase independent manner
Wang, Z., Fu, M., Wang, L., Liu, J., Li, Y., Brakebusch, Cord Herbert & Mei, Q., 7 May 2013, In: Journal of Biological Chemistry.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis
Vadodaria, K. C., Brakebusch, Cord Herbert, Suter, U. & Jessberger, S., 16 Jan 2013, In: Journal of Neuroscience. 33, 3, p. 1179-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo
Luckashenak, N., Wähe, A., Breit, K., Brakebusch, Cord Herbert & Brocker, T., 1 Jan 2013, In: Journal of Immunology. 190, 1, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1
Pedersen, E. D. K., Wang, Z., Stanley, A., Peyrollier, K., Rösner, L. M., Werfel, T., Quondamatteo, F. & Brakebusch, Cord Herbert, 15 Nov 2012, In: Journal of Cell Science. 125, Pt 22, p. 5379-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPases and Nox dependent ROS production in skin. Is there a connection?
Stanley, A., Hynes, A., Brakebusch, Cord Herbert & Quondamatteo, F., Nov 2012, In: Histology and Histopathology. 27, 11, p. 1395-406 12 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Opposing roles for RhoH GTPase during T-cell migration and activation
Baker, C. M., Comrie, W. A., Hyun, Y., Chung, H., Fedorchuk, C. A., Lim, K., Brakebusch, Cord Herbert, McGrath, J. L., Waugh, R. E., Meier-Schellersheim, M. & Kim, M., 26 Jun 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10474-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FMNL2 drives actin-based protrusion and migration downstream of Cdc42
Block, J., Breitsprecher, D., Kühn, S., Winterhoff, M., Kage, F., Geffers, R., Duwe, P., Rohn, J. L., Baum, B., Brakebusch, Cord Herbert, Geyer, M., Stradal, T. E. B., Faix, J. & Rottner, K., 5 Jun 2012, In: Current Biology. 22, 11, p. 1005-12 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPase function in development: How in vivo models change our view
Pedersen, E. & Brakebusch, Cord Herbert, 29 May 2012, In: Experimental Cell Research. 318, 14, p. 1779-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Podocyte-specific loss of cdc42 leads to congenital nephropathy
Scott, R. P., Hawley, S. P., Ruston, J., Du, J., Brakebusch, Cord Herbert, Jones, N. & Pawson, T., 19 Apr 2012, In: Journal of the American Society of Nephrology. 23, 7, p. 1149-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A radial glia-specific role of RhoA in double cortex formation
Cappello, S., Böhringer, C. R. J., Bergami, M., Conzelmann, K., Ghanem, A., Tomassy, G. S., Arlotta, P., Mainardi, M., Allegra, M., Caleo, M., van Hengel, J., Brakebusch, Cord Herbert & Götz, M., 8 Mar 2012, In: Neuron. 73, 5, p. 911-24 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
Sakamori, R., Das, S., Yu, S., Feng, S., Stypulkowski, E., Guan, Y., Douard, V., Tang, W., Ferraris, R. P., Harada, A., Brakebusch, Cord Herbert, Guo, W. & Gao, N., 1 Mar 2012, In: Journal of Clinical Investigation. 122, 3, p. 1052-65 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A function for Rac1 in the terminal differentiation and pigmentation of hair
Behrendt, K., Klatte, J., Pofahl, R., Bloch, W., Smyth, N., Tscharntke, M., Krieg, T., Paus, R., Niessen, C., Niemann, C., Brakebusch, Cord Herbert & Haase, I., 24 Jan 2012, In: Journal of Cell Science. 125, Pt 4, p. 896-905 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood
Anttonen, T., Kirjavainen, A., Belevich, I., Laos, M., Richardson, W. D., Jokitalo, E., Brakebusch, Cord Herbert & Pirvola, U., 2012, In: Scientific Reports. 2, p. 978Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Proteomic analyses reveal divergent ubiquitylation site patterns in murinetissues
Wagner, S. A., Beli, P., Weinert, B. T., Schölz, C. F., Kelstrup, C. D., Young, C., Nielsen, Michael Lund, Olsen, Jesper Velgaard, Brakebusch, Cord Herbert & Choudhary, Chunaram, 2012, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
Pleines, I., Hagedorn, I., Gupta, S., May, F., Chakarova, L., van Hengel, J., Offermanns, S., Krohne, G., Kleinschnitz, C., Brakebusch, Cord Herbert & Nieswandt, B., 1 Nov 2011, In: Blood. 119, 4, p. 1054-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo
Robel, S., Bardehle, S., Lepier, A., Brakebusch, Cord Herbert & Götz, M., 31 Aug 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 35, p. 12471-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 Controls Vascular Network Assembly Through Protein Kinase C{iota} During Embryonic Vasculogenesis
Qi, Y., Liu, J., Wu, X., Brakebusch, Cord Herbert, Leitges, M., Han, Y., Corbett, S. A., Lowry, S. F., Graham, A. M. & Li, S., 1 Aug 2011, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 8, p. 1861-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool
Herzog, D., Loetscher, P., van Hengel, J., Knüsel, S., Brakebusch, Cord Herbert, Taylor, V., Suter, U. & Relvas, J. B., 30 Mar 2011, In: Journal of Neuroscience. 31, 13, p. 5120-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
Jackson, B., Peyrollier, K., Pedersen, E., Basse, A., Karlsson, R., Wang, Z., Lefever, T., Ochsenbein, A. M., Schmidt, G., Aktories, K., Stanley, A., Quondamatteo, F., Ladwein, M., Rottner, K., van Hengel, J. & Brakebusch, Cord Herbert, 1 Mar 2011, In: Molecular Biology of the Cell. 22, 5, p. 593-605 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection
Porubsky, S., Wang, S., Kiss, E., Dehmel, S., Bonrouhi, M., Dorn, T., Luckow, B., Brakebusch, Cord Herbert & Gröne, H., 1 Jan 2011, In: European Journal of Immunology. 41, 1, p. 76-88 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Generation and analysis of genetically modified mice
Brakebusch, Cord Herbert, 2011, Handbook of Laboratory Animal Science: Essential Principles and Practices. Hau, J. & Schapiro, SJ. (eds.). 3rd ed. Boca Raton, London, New York: CRC Press, Vol. 1.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Mouse as a Model Organism: From Animals to Cells
Brakebusch, Cord Herbert (ed.) & Pihlajaniemi, T. (ed.), 2011, Dordrecht: Springer. 165 p.Research output: Book/Report › Anthology › Research › peer-review
- Accepted/In press
Rho GTPase knockout induction in primary keratinocytes from adult mice
Pedersen, E. D. K., Basse, A. L., Lefever, T., Peyrollier, K. C. & Brakebusch, Cord Herbert, 2011, (Accepted/In press) Methods in Rho GTPases. Rivero, F. (ed.). New York: Humana PressResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2010
- Published
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets
Pleines, I., Eckly, A., Elvers, M., Hagedorn, I., Eliautou, S., Bender, M., Wu, X., Lanza, F., Gachet, C., Brakebusch, Cord Herbert & Nieswandt, B., 2010, In: Blood. 115, 16, p. 3364-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways
Lefever, T., Pedersen, E., Basse, A., Paus, R., Quondamatteo, F., Stanley, A. C., Langbein, L., Wu, X., Wehland, J., Lommel, S. & Brakebusch, Cord Herbert, 2010, In: Journal of Cell Science. 123, Pt 1, p. 128-40 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
Wang, Z., Pedersen, E. D. K., Basse, A., Lefever, T., Peyrollier, K., Kapoor, S., Mei, Q., Karlsson, R., Chrostek-Grashoff, A. & Brakebusch, Cord Herbert, 2010, In: Oncogene. 29, 23, p. 3362-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 is essential for basement membrane-dependent epiblast survival
He, X., Liu, J., Qi, Y., Brakebusch, Cord Herbert, Chrostek-Grashoff, A., Edgar, D., Yurchenco, P. D., Corbett, S. A., Lowry, S. F., Graham, A. M., Han, Y. & Li, S., 2010, In: Molecular and Cellular Biology. 30, 14, p. 3569-81 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 regulates neuronal polarization through the WAVE complex
Tahirovic, S., Hellal, F., Neukirchen, D., Hindges, R., Garvalov, B. K., Flynn, K. C., Stradal, T. E., Chrostek-Grashoff, A., Brakebusch, Cord Herbert & Bradke, F., 2010, In: Journal of Neuroscience. 30, 20, p. 6930-43 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPase function in cell morphogenesis
Pedersen, E. D. K. & Brakebusch, Cord Herbert, 2010, ENCYCLOPEDIA OF LIFE SCIENCES. WileyResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain
Leone, D. P., Srinivasan, K., Brakebusch, Cord Herbert & McConnell, S. K., 2010, In: Developmental Neurobiology. 70, 9, p. 659-78 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Haditsch, U., Leone, D. P., Farinelli, M., Chrostek-Grashoff, A., Brakebusch, Cord Herbert, Mansuy, I. M., McConnell, S. K. & Palmer, T. D., 2009, In: Molecular and Cellular Neuroscience. 41, 4, p. 409-19 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion
Piwko-Czuchra, A., Koegel, H., Meyer, H., Bauer, M., Werner, S., Brakebusch, Cord Herbert & Fässler, R., 2009, In: PLoS ONE. 4, 5, p. e5488Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
Bauer, M., Brakebusch, Cord Herbert, Coisne, C., Sixt, M., Wekerle, H., Engelhardt, B. & Fässler, R., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 6, p. 1920-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration
Lammermann, T., Renkawitz, J., Wu, X., Hirsch, K., Brakebusch, Cord Herbert & Sixt, M., 2009, In: Blood.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42-mediated tubulogenesis controls cell specification
Kesavan, G., Sand, F. W., Greiner, T. U., Johansson, J. K., Kobberup, S., Wu, X., Brakebusch, Cord Herbert & Semb, Tor Henrik, 2009, In: Cell. 139, 4, p. 791-801 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice
Yuan, H., Zhang, H., Wu, X., Zhang, Z., Du, D., Zhou, W., Zhou, S., Brakebusch, Cord Herbert & Chen, Z., 2009, In: Hepatology. 49, 1, p. 240-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rho GTPase function in tumorigenesis
Karlsson, R., Pedersen, E. D. K., Wang, Z. & Brakebusch, Cord Herbert, 2009, In: BBA General Subjects.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1
Fuchs, S., Herzog, D., Sumara, G., Büchmann-Møller, S., Civenni, G., Wu, X., Chrostek-Grashoff, A., Suter, U., Ricci, R., Relvas, J. B., Brakebusch, Cord Herbert & Sommer, L., 2009, In: Cell Stem Cell. 4, 3, p. 236-47 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse
Vasyutina, E., Martarelli, B., Brakebusch, Cord Herbert, Wende, H. & Birchmeier, C., 2009, In: Proceedings of the National Academy of Science of the United States of America. 106, 22, p. 8935-40 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Genetically Modified Mice in Medical and Pharmaceutical Research
Brakebusch, Cord Herbert, 5 Feb 2008, Modern Biopharmaceuticals: Design, Development and Optimization. Wiley-VCH, Vol. 2. p. 649-660 12 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1
Du, D., Pedersen, E., Wang, Z., Karlsson, R., Chen, Z., Wu, X. & Brakebusch, Cord Herbert, 2008, In: Experimental Cell Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.
van Hengel, J., D'Hooge, P., Hooghe, B., Wu, X., Libbrecht, L., De Vos, R., Quondamatteo, F., Klempt, M., Brakebusch, Cord Herbert & van Roy, F., 2008, In: Gastroenterology. 134, 3, p. 781-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functions of Rac1 in the epidermis
Haase, I. & Brakebusch, Cord Herbert, 2008, In: Journal of Investigative Dermatology. 128, Suppl. 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatocyte dysplasia and tumor nodule formation in CDC42-deficient mouse liver
Hengel, J. V., D'Hooge, P., Wu, X. W., Libbrecht, L., Vos, R. D., Brakebusch, Cord Herbert & Roy, F. V., 2008, In: Acta Clinica Belgica. 63, 1, p. 56-56Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pigmentation defect due to the deficiency of Rac1 in differentiated parts of the hair follicle
Behrundt, K., Brakebusch, Cord Herbert, Pofahl, R., Krieg, T. & Hasse, I., 2008, In: Journal of Investigative Dermatology. 128, Suppl. 1Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Pleines, I., Elvers, M., Strehl, A., Pozgajova, M., Varga-Szabo, D., May, F., Chrostek-Grashoff, A., Brakebusch, Cord Herbert & Nieswandt, B., 2008, In: Pflügers Archiv: European Journal of Physiology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.
Bosse, T., Ehinger, J., Czuchra, A., Benesch, S., Steffen, A., Wu, X., Schloen, K., Niemann, H. H., Scita, G., Stradal, T. E. B., Brakebusch, Cord Herbert & Rottner, K., 2007, In: Molecular and Cellular Biology. 27, 19, p. 6615-28 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Wu, X., Li, S., Chrostek-Grashoff, A., Czuchra, A., Meyer, H., Yurchenco, P. D. & Brakebusch, Cord Herbert, 2007, In: Developmental Dynamics. 236, 10, p. 2767-78 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 regulates cofilin during the establishment of neuronal polarity.
Garvalov, B. K., Flynn, K. C., Neukirchen, D., Meyn, L., Teusch, N., Wu, X., Brakebusch, Cord Herbert, Bamburg, J. R. & Bradke, F., 2007, In: Journal of Neuroscience. 27, 48, p. 13117-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
Benninger, Y., Thurnherr, T., Pereira, J. A., Krause, S., Wu, X., Chrostek-Grashoff, A., Herzog, D., Nave, K., Franklin, R. J. M., Meijer, D., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2007, In: Journal of Cell Biology. 177, 6, p. 1051-61 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.
Tscharntke, M., Pofahl, R., Chrostek-Grashoff, A., Smyth, N., Niessen, C., Niemann, C., Hartwig, B., Herzog, V., Klein, H. W., Krieg, T., Brakebusch, Cord Herbert & Haase, I., 2007, In: Journal of Cell Science. 120, Pt 8, p. 1480-90 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Leukocyte extravasation as a target for anti-inflammatory therapy - Which molecule to choose? (vol 14, pg 70, 2005)
Boehncke, W. H., Schon, M. P., Giromolomi, G., Griffiths, C., Bos, J. D., Thestrup-Pedersen, K., Cavani, A., Nestle, F., Bonish, B. K., Campbell, J. J., Brakebusch, Cord Herbert & Nickoloff, B., 2007, In: Experimental Dermatology. 16, 9, p. 778-778Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
Bungartz, G., Stiller, S., Bauer, M., Müller, W., Schippers, A., Wagner, N., Fässler, R. & Brakebusch, Cord Herbert, 2006, In: Blood. 108, 6, p. 1857-64 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
Thurnherr, T., Benninger, Y., Wu, X., Chrostek, A., Krause, S. M., Nave, K., Franklin, R. J. M., Brakebusch, Cord Herbert, Suter, U. & Relvas, J. B., 2006, In: Journal of Neuroscience. 26, 40, p. 10110-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu, X., Quondamatteo, F., Lefever, T., Czuchra, A., Meyer, H., Chrostek, A., Paus, R., Langbein, L. & Brakebusch, Cord Herbert, 2006, In: Genes & Development. 20, 5, p. 571-85 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Wu, X., Quondamatteo, F. & Brakebusch, Cord Herbert, 2006, In: Matrix Biology. 25, 8, p. 466-74 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analysis of beta1 integrin "activation motifs" in mice.
Czuchra, A., Meyer, H., Legate, K. R., Brakebusch, Cord Herbert & Fässler, R., 2006, In: Journal of Cell Biology. 174, 6, p. 889-99 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.
Breau, M. A., Pietri, T., Eder, O., Blanche, M., Brakebusch, Cord Herbert, Fässler, R., Thiery, J. P. & Dufour, S., 2006, In: Development. 133, 9, p. 1725-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis.
Chrostek, A., Wu, X., Quondamatteo, F., Hu, R., Sanecka, A., Niemann, C., Langbein, L., Haase, I. & Brakebusch, Cord Herbert, 2006, In: Molecular and Cellular Biology. 26, 18, p. 6957-70 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Dorn, T., Kuhn, U., Bungartz, G., Stiller, S., Bauer, M., Ellwart, J., Peters, T., Scharffetter-Kochanek, K., Semmrich, M., Laschinger, M., Holzmann, B., Klinkert, W. E. F., Straten, P. T., Køllgaard, T., Sixt, M. & Brakebusch, Cord Herbert, 2006, In: Blood. 109, 6, p. 2346-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Cappello, S., Attardo, A., Wu, X., Iwasato, T., Itohara, S., Wilsch-Bräuninger, M., Eilken, H. M., Rieger, M. A., Schroeder, T. T., Huttner, W. B., Brakebusch, Cord Herbert & Götz, M., 2006, In: Nature Neuroscience. 9, 9, p. 1099-107 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Threonine 788 in integrin subunit beta1 regulates integrin activation.
Nilsson, S., Kaniowska, D., Brakebusch, Cord Herbert, Fässler, R. & Johansson, S., 2006, In: Experimental Cell Research. 312, 6, p. 844-53 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.
Cordes, N., Seidler, J., Durzok, R., Geinitz, H. & Brakebusch, Cord Herbert, 2006, In: Oncogene. 25, 9, p. 1378-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
Keratinocyte Migration in Wound Healing
Brakebusch, Cord Herbert, 9 Aug 2005, Cell Migration in Development and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, p. 275-298 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Integrin blockade as therapy in chronic inflammation
Brakebusch, Cord Herbert, 1 May 2005, In: Experimental Dermatology. 14, 5, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Czuchra, A., Wu, X., Meyer, H., van Hengel, J., Schroeder, T., Geffers, R., Rottner, K. & Brakebusch, Cord Herbert, 2005, In: Molecular Biology of the Cell. 16, 10, p. 4473-84 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.
Seidler, J., Durzok, R., Brakebusch, Cord Herbert & Cordes, N., 2005, In: Radiotherapy & Oncology. 76, 2, p. 129-34 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Leukocyte extravasation as a target for anti-inflammatory therapy - Which molecule to choose?
Boehncke, W., Schön, M. P., Girolomoni, G., Giromolomi, G., Griffiths, C., Bos, J. D., Thestrup-Pedersen, K., Cavani, A., Nestle, F., Bonish, B. K., Campbell, J. J., Brakebusch, Cord Herbert & Nickoloff, B., 2005, In: Experimental Dermatology. 14, 1, p. 70-80 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of neural progenitor proliferation and survival by beta1 integrins.
Leone, D. P., Relvas, J. B., Campos, L. S., Hemmi, S., Brakebusch, Cord Herbert, Fässler, R., Ffrench-Constant, C. & Suter, U., 2005, In: Journal of Cell Science. 118, Pt 12, p. 2589-99 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
beta 1 integrin function in vivo: adhesion, migration and more.
Brakebusch, Cord Herbert & Fässler, R., 2005, In: Cancer Metastasis Review. 24, 3, p. 403-11 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
Marsal, J., Brakebusch, Cord Herbert, Bungartz, G., Fässler, R. & Agace, W. W., 2005, In: European Journal of Immunology. 35, 6, p. 1805-11 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance.
Campos, L. S., Leone, D. P., Relvas, J. B., Brakebusch, Cord Herbert, Fässler, R., Suter, U. & ffrench-Constant, C., 2004, In: Development. 131, 14, p. 3433-44 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.
Pietri, T., Eder, O., Breau, M. A., Topilko, P., Blanche, M., Brakebusch, Cord Herbert, Fässler, R., Thiery, J. & Dufour, S., 2004, In: Development. 131, 16, p. 3871-83 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.
Xanthoulea, S., Pasparakis, M., Kousteni, S., Brakebusch, Cord Herbert, Wallach, D., Bauer, J., Lassmann, H. & Kollias, G., 2004, In: Journal of Experimental Medicine. 200, 3, p. 367-76 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Aszodi, A., Hunziker, E. B., Brakebusch, Cord Herbert & Fässler, R., 2003, In: Genes & Development. 17, 19, p. 2465-79 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
Kuijpers, M. J. E., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, Cord Herbert, Offermanns, S., Fässler, R., Heemskerk, J. W. M. & Nieswandt, B., 2003, In: The FASEB Journal. 17, 6, p. 685-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.
Sitnicka, E., Brakebusch, Cord Herbert, Martensson, I., Svensson, M., Agace, W. W., Sigvardsson, M., Buza-Vidas, N., Bryder, D., Cilio, C. M., Ahlenius, H., Maraskovsky, E., Peschon, J. J. & Jacobsen, S. E. W., 2003, In: Journal of Experimental Medicine. 198, 10, p. 1495-506 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., Brandt, C., Löscher, W., Grimberg, D., Dresbach, T., Hempelmann, A., Hassan, H., Balschun, D., Frey, J. U., Brandstätter, J. H., Garner, C. C. & 2 others, , 2003, In: Neuron. 37, 5, p. 787-800 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.
Grüner, S., Prostredna, M., Schulte, V., Krieg, T., Eckes, B., Brakebusch, Cord Herbert & Nieswandt, B., 2003, In: Blood. 102, 12, p. 4021-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.
He, Z., Brakebusch, Cord Herbert, Fässler, R., Kreidberg, J. A., Primakoff, P. & Myles, D. G., 2003, In: Developmental Biology. 254, 2, p. 226-37 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The integrin-actin connection, an eternal love affair.
Brakebusch, Cord Herbert & Fässler, R., 2003, In: EMBO Journal. 22, 10, p. 2324-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.
Grose, R., Hutter, C., Bloch, W., Thorey, I., Watt, F. M., Fässler, R., Brakebusch, Cord Herbert & Werner, S., 2002, In: Development. 129, 9, p. 2303-15 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
Brakebusch, Cord Herbert, Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D. & Fässler, R., 2002, In: Immunity. 16, 3, p. 465-77 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Brakebusch, Cord Herbert, Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., Montag, D., Gundelfinger, E. D. & Fässler, R., 2002, In: Molecular and Cellular Biology. 22, 21, p. 7417-27 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrins in invasive growth.
Brakebusch, Cord Herbert, Bouvard, D., Stanchi, F., Sakai, T. & Fässler, R., 2002, In: Journal of Clinical Investigation. 109, 8, p. 999-1006 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.
Gustavsson, A., Armulik, A., Brakebusch, Cord Herbert, Fässler, R., Johansson, S. & Fällman, M., 2002, In: Journal of Cell Science. 115, Pt 13, p. 2669-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis.
Danen, E. H. J., Sonneveld, P., Brakebusch, Cord Herbert, Fassler, R. & Sonnenberg, A., 2002, In: Journal of Cell Biology. 159, 6, p. 1071-86 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.
Henry, M. D., Satz, J. S., Brakebusch, Cord Herbert, Costell, M., Gustafsson, E., Fässler, R. & Campbell, K. P., 2001, In: Journal of Cell Science. 114, Pt 6, p. 1137-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional consequences of integrin gene mutations in mice.
Bouvard, D., Brakebusch, Cord Herbert, Gustafsson, E., Aszódi, A., Bengtsson, T., Berna, A. & Fässler, R., 2001, In: Circulation Research. 89, 3, p. 211-23 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
Nieswandt, B., Brakebusch, Cord Herbert, Bergmeier, W., Schulte, V., Bouvard, D., Mokhtari-Nejad, R., Lindhout, T., Heemskerk, J. W., Zirngibl, H. & Fässler, R., 2001, In: EMBO Journal. 20, 9, p. 2120-30 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation.
Chidgey, M., Brakebusch, Cord Herbert, Gustafsson, E., Cruchley, A., Hail, C., Kirk, S., Merritt, A., North, A., Tselepis, C., Hewitt, J., Byrne, C., Fassler, R. & Garrod, D., 2001, In: Journal of Cell Biology. 155, 5, p. 821-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurocan is dispensable for brain development.
Zhou, X. H., Brakebusch, Cord Herbert, Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., Buettner, R., Gundelfinger, E. D. & Fässler, R., 2001, In: Molecular and Cellular Biology. 21, 17, p. 5970-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha.
Bergmeier, W., Bouvard, D., Eble, J. A., Mokhtari-Nejad, R., Schulte, V., Zirngibl, H., Brakebusch, Cord Herbert, Fässler, R. & Nieswandt, B., 2001, In: Journal of Biological Chemistry. 276, 27, p. 25121-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
Sasaki, T., Göhring, W., Mann, K., Brakebusch, Cord Herbert, Yamada, Y., Fässler, R. & Timpl, R., 2001, In: Journal of Molecular Biology. 314, 4, p. 751-63 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice.
Gustafsson, E., Brakebusch, Cord Herbert, Hietanen, K. & Fässler, R., 2001, In: Journal of Cell Science. 114, Pt 4, p. 671-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
Discoidin domain receptor 1 is activated independently of beta(1) integrin.
Vogel, W., Brakebusch, Cord Herbert, Fässler, R., Alves, F., Ruggiero, F. & Pawson, T., 2000, In: Journal of Biological Chemistry. 275, 8, p. 5779-84 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow.
Potocnik, A. J., Brakebusch, Cord Herbert & Fässler, R., 2000, In: Immunity. 12, 6, p. 653-63 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.
Dixon, J., Brakebusch, Cord Herbert, Fässler, R. & Dixon, M. J., 2000, In: Human Molecular Genetics. 9, 10, p. 1473-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes.
Brakebusch, Cord Herbert, Grose, R., Quondamatteo, F., Ramirez, A., Jorcano, J. L., Pirro, A., Svensson, M., Herken, R., Sasaki, T., Timpl, R., Werner, S. & Fässler, R., 2000, In: EMBO Journal. 19, 15, p. 3990-4003 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
Iba, K., Albrechtsen, Reidar, Gilpin, B., Frohlich, C., Loechel, F., Zolkiewska, A., Ishiguro, K., Kojima, T., Liu, W., Langford, J. K., Sanderson, R. D., Brakebusch, Cord Herbert, Fässler, R. & Wewer, Ulla M., 2000, In: Journal of Cell Biology. 149, 5, p. 1143-56 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.
Brakebusch, Cord Herbert, Wennerberg, K., Krell, H. W., Weidle, U. H., Sallmyr, A., Johansson, S. & Fässler, R., 1999, In: Oncogene. 18, 26, p. 3852-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.
Gimond, C., van Der Flier, A., van Delft, S., Brakebusch, Cord Herbert, Kuikman, I., Collard, J. G., Fässler, R. & Sonnenberg, A., 1999, In: Journal of Cell Biology. 147, 6, p. 1325-40 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integrin gene targeting.
Talts, J. F., Brakebusch, Cord Herbert & Fässler, R., 1999, In: Methods in Molecular Biology. 129, p. 153-87 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Isolation and functional characterization of the human 90K promoter.
Brakebusch, Cord Herbert, Sures, I., Jallal, B., Mossie, K., Fusco, O., Iacobelli, S. & Ullrich, A., 1999, In: Genomics. 57, 2, p. 268-78 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
90K (MAC-2 BP) gene expression in breast cancer and evidence for the production of 90K by peripheral-blood mononuclear cells.
Fusco, O., Querzoli, P., Nenci, I., Natoli, C., Brakebusch, Cord Herbert, Ullrich, A. & Iacobelli, S., 1998, In: International Journal of Cancer. 79, 1, p. 23-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effect on TCR:CD3 stimulation of a 90-kD glycoprotein (gp90/Mac-2BP), a member of the scavenger receptor cysteine-rich domain protein family.
Silvestri, B., Calderazzo, F., Coppola, V., Rosato, A., Iacobelli, S., Natoli, C., Ullrich, A., Sures, I., Azam, M., Brakebusch, Cord Herbert, Chieco-Bianchi, L. & Amadori, A., 1998, In: Clinical and Experimental Immunology. 113, 3, p. 394-400 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.
Sasaki, T., Brakebusch, Cord Herbert, Engel, J. & Timpl, R., 1998, In: EMBO Journal. 17, 6, p. 1606-13 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Beta 1 integrin is essential for teratoma growth and angiogenesis.
Bloch, W., Forsberg, E., Lentini, S., Brakebusch, Cord Herbert, Martin, K., Krell, H. W., Weidle, U. H., Addicks, K. & Fässler, R., 1997, In: Journal of Cell Biology. 139, 1, p. 265-78 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.
Brakebusch, Cord Herbert, Jallal, B., Fusco, O., Iacobelli, S. & Ullrich, A., 1997, In: Journal of Biological Chemistry. 272, 6, p. 3674-82 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
Brakebusch, Cord Herbert, Hirsch, E., Potocnik, A. & Fässler, R., 1997, In: Journal of Cell Science. 110 ( Pt 23), p. 2895-904 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sequence and chromosomal localization of the mouse brevican gene.
Rauch, U., Meyer, H., Brakebusch, Cord Herbert, Seidenbecher, C., Gundelfinger, E. D., Beier, D. R. & Fässler, R., 1997, In: Genomics. 44, 1, p. 15-21 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Functional discrepancies between tumor necrosis factor and lymphotoxin alpha explained by trimer stability and distinct receptor interactions.
Schuchmann, M., Hess, S., Bufler, P., Brakebusch, Cord Herbert, Wallach, D., Porter, A., Riethmüller, G. & Engelmann, H., 1995, In: European Journal of Immunology. 25, 8, p. 2183-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppression of tumor growth in vivo by local and systemic 90K level increase.
Jallal, B., Powell, J., Zachwieja, J., Brakebusch, Cord Herbert, Germain, L., Jacobs, J., Iacobelli, S. & Ullrich, A., 1995, In: Cancer Research. 55, 15, p. 3223-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.
Bigda, J., Beletsky, I., Brakebusch, Cord Herbert, Varfolomeev, Y., Engelmann, H., Bigda, J., Holtmann, H. & Wallach, D., 1994, In: Journal of Experimental Medicine. 180, 2, p. 445-60 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural requirements for inducible shedding of the p55 tumor necrosis factor receptor.
Brakebusch, Cord Herbert, Varfolomeev, E. E., Batkin, M. & Wallach, D., 1994, In: Journal of Biological Chemistry. 269, 51, p. 32488-96 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
- Published
Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.
Brakebusch, Cord Herbert, Nophar, Y., Kemper, O., Engelmann, H. & Wallach, D., 1992, In: EMBO Journal. 11, 3, p. 943-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells.
Winzen, R., Wallach, D., Engelmann, H., Nophar, Y., Brakebusch, Cord Herbert, Kemper, O., Resch, K. & Holtmann, H., 1992, In: Journal of Immunology. 148, 11, p. 3454-60 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.
Aderka, D., Engelmann, H., Maor, Y., Brakebusch, Cord Herbert & Wallach, D., 1992, In: Journal of Experimental Medicine. 175, 2, p. 323-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
- Published
Mechanisms controlling the level of receptors for tumor necrosis factor.
Holtmann, H., Brakebusch, Cord Herbert, König, M., Klocke, R., Winzen, R., Resch, K. & Wallach, D., 1991, In: Agents and Actions. 32, 1-2, p. 106-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Soluble and cell surface receptors for tumor necrosis factor.
Wallach, D., Engelmann, H., Nophar, Y., Aderka, D., Kemper, O., Hornik, V., Holtmann, H. & Brakebusch, Cord Herbert, 1991, In: Agents and actions. Supplements. 35, p. 51-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
- Published
Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
Engelmann, H., Holtmann, H., Brakebusch, Cord Herbert, Avni, Y. S., Sarov, I., Nophar, Y., Hadas, E., Leitner, O. & Wallach, D., 1990, In: Journal of Biological Chemistry. 265, 24, p. 14497-504 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.
Nophar, Y., Kemper, O., Brakebusch, Cord Herbert, Englemann, H., Zwang, R., Aderka, D., Holtmann, H. & Wallach, D., 1990, In: EMBO Journal. 9, 10, p. 3269-78 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5296
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Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency
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205
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Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice
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197
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The Interaction between Laminin-332 and α3β1 Integrin Determines Differentiation and Maintenance of CAFs, and Supports Invasion of Pancreatic Duct Adenocarcinoma Cells
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