All individuals of a plant species resist attack by most pathogens due to their “non-host resistance”. Only a limited number of microbes are able to overcome this resistance, and can be seen as pathogens of the species. In this way non-host resistance is extremely broad-range and durable. On the other hand, host resistance, where only a subset of plant of a species exhibits resistance towards a pathogen, is often narrow in range and vulnerable for breakdown. Therefore non-host resistance is predicted to have a potential in plant disease control, provided we understand the mechanisms behind. It is conceivable that understanding non-host resistance will go hand-in-hand with understanding host resistance and the process of pathogen attack. As such it becomes clear that non-host resistance can be the combined action of a number of defence components functioning along the steps of pathogen ingress towards establishing disease. This is also true for host resistance, and it has been documented that several of these defence components are shared between the two types of resistance. But still it is unknown what in fact determines the difference between them.