What is the profile of overweight individuals who are unsuccessful responders to a low-energy diet? A PREVIEW sub-study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt


  • Angelo Tremblay
  • Mikael Fogelholm
  • Elli Jalo
  • Margriet S Westerterp-Plantenga
  • Tanja C Adam
  • Maija Huttunen-Lenz
  • Gareth Stratton
  • Tony Lam
  • Teodora Handjieva-Darlenska
  • Svetoslav Handjiev
  • J Alfredo Martinez
  • Ian A Macdonald
  • Elizabeth J Simpson
  • Jennie Brand-Miller
  • Roslyn Muirhead
  • Sally D Poppitt
  • Marta P Silvestre
  • Thomas Meinert Larsen
  • Pia Siig Vestentoft
  • Wolfgang Schlicht
  • Vicky Drapeau
This study was performed to evaluate the profile of overweight individuals with
pre-diabetes enrolled in PREVIEW who were unable to achieve a body weight loss
of ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseline profile reflected potential stress-related vulnerability that predicted a reduced response of body weight to a LED programme. The mean daily energy deficit maintained by unsuccessful weight responders of both sexes was less than the estimated level in successful female (656 vs. 1,299 kcal, p < 0.01) and male (815 vs. 1,659 kcal, p < 0.01) responders. Despite this smaller energy deficit, unsuccessful responders displayed less favorable changes in susceptibility to hunger and appetite sensations. They also did not benefit from the intervention regarding the ability to improve sleep quality. In summary, these results show that some individuals display a behavioral vulnerability which may
reduce the ability to lose weight in response to a diet-based weight loss program. They also suggest that this vulnerability may be accentuated by a prolonged diet restriction.
TidsskriftFrontiers in Nutrition
Antal sider9
StatusUdgivet - 2021

Bibliografisk note

CURIS 2021 NEXS 341

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