The Pictet-Spengler reaction in solid-phase combinatorial chemistry

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The Pictet-Spengler reaction is an important reaction for the generation of tetrahydro-beta-carbolines and tetrahydroisoquinoline ring systems, which exhibit a range of biological and pharmacological properties. This review covers the solid-phase Pictet-Spengler reaction, as employed in solid-phase routes toward a range of complex heterocyclic ring systems, with focus on experimental conditions, efficiency and diastereoselectivity. This is illustrated by the application of this reaction to the synthesis of combinatorial libraries, natural product analogs and drug-like scaffolds.

TidsskriftCurrent Opinion in Drug Discovery & Development
Udgave nummer6
Sider (fra-til)801-14
Antal sider14
StatusUdgivet - nov. 2003

ID: 158554756