Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. / Svenningsen, Søren Wedel; Frederiksen, Rikki Franklin; Counil, Claire; Ficker, Mario; Leisner, Jørgen J.; Christensen, Jørn Bolstad.

I: Molecules, Bind 25, Nr. 6, 1389, 2020, s. 1-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Svenningsen, SW, Frederiksen, RF, Counil, C, Ficker, M, Leisner, JJ & Christensen, JB 2020, 'Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate', Molecules, bind 25, nr. 6, 1389, s. 1-13. https://doi.org/10.3390/molecules25061389

APA

Svenningsen, S. W., Frederiksen, R. F., Counil, C., Ficker, M., Leisner, J. J., & Christensen, J. B. (2020). Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. Molecules, 25(6), 1-13. [1389]. https://doi.org/10.3390/molecules25061389

Vancouver

Svenningsen SW, Frederiksen RF, Counil C, Ficker M, Leisner JJ, Christensen JB. Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. Molecules. 2020;25(6):1-13. 1389. https://doi.org/10.3390/molecules25061389

Author

Svenningsen, Søren Wedel ; Frederiksen, Rikki Franklin ; Counil, Claire ; Ficker, Mario ; Leisner, Jørgen J. ; Christensen, Jørn Bolstad. / Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate. I: Molecules. 2020 ; Bind 25, Nr. 6. s. 1-13.

Bibtex

@article{04615420200848009ad597cf246e68b9,
title = "Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate",
abstract = "Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.",
keywords = "Antimicrobial compounds, Ciprofloxacin, Dendrimers",
author = "Svenningsen, {S{\o}ren Wedel} and Frederiksen, {Rikki Franklin} and Claire Counil and Mario Ficker and Leisner, {J{\o}rgen J.} and Christensen, {J{\o}rn Bolstad}",
year = "2020",
doi = "10.3390/molecules25061389",
language = "English",
volume = "25",
pages = "1--13",
journal = "Molecules",
issn = "1420-3049",
publisher = "M D P I AG",
number = "6",

}

RIS

TY - JOUR

T1 - Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

AU - Svenningsen, Søren Wedel

AU - Frederiksen, Rikki Franklin

AU - Counil, Claire

AU - Ficker, Mario

AU - Leisner, Jørgen J.

AU - Christensen, Jørn Bolstad

PY - 2020

Y1 - 2020

N2 - Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

AB - Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

KW - Antimicrobial compounds

KW - Ciprofloxacin

KW - Dendrimers

U2 - 10.3390/molecules25061389

DO - 10.3390/molecules25061389

M3 - Journal article

C2 - 32197523

AN - SCOPUS:85082058612

VL - 25

SP - 1

EP - 13

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 6

M1 - 1389

ER -

ID: 240005690