Skelettmuskulatur, körperliche Aktivität und Gesundheit
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Skelettmuskulatur, körperliche Aktivität und Gesundheit. / Saltin, B; Helge, Jørn Wulff.
I: Orthopaede, Bind 29, Nr. 11, 01.11.2000, s. 941-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Skelettmuskulatur, körperliche Aktivität und Gesundheit
AU - Saltin, B
AU - Helge, Jørn Wulff
PY - 2000/11/1
Y1 - 2000/11/1
N2 - The metabolic capacity of skeletal muscle plays a significant role for insulin sensitivity and the blood lipid profile. The metabolic capacity of the muscle is a function of the individual's physical activity level. This is also true for the content of type IIa muscle fibres, which is reduced, and the number of capillaries, which is elevated with muscle usage. Several of these skeletal muscle features are risk factors for or linked with life-style induced diseases such as type II diabetes, hypertension, hyperlipemia and obesity. The central role of the skeletal muscle and its functional metabolic capacity for life style diseases highlights the importance of people maintaining daily physical activity. This article focuses on the link between the metabolic capacity of skeletal muscle and the metabolic syndrome and briefly discusses the explanations for this relationship. As one important aspect if skeletal muscle has a high capacity for lipid oxidation, then more saturated fatty acids are oxidised and more unsaturated fatty acids are built in the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Moreover, the article points at the role of these fatty acids in activating genes via the PPAR-receptor system essential for enzyme and transport proteins in the lipid metabolism.
AB - The metabolic capacity of skeletal muscle plays a significant role for insulin sensitivity and the blood lipid profile. The metabolic capacity of the muscle is a function of the individual's physical activity level. This is also true for the content of type IIa muscle fibres, which is reduced, and the number of capillaries, which is elevated with muscle usage. Several of these skeletal muscle features are risk factors for or linked with life-style induced diseases such as type II diabetes, hypertension, hyperlipemia and obesity. The central role of the skeletal muscle and its functional metabolic capacity for life style diseases highlights the importance of people maintaining daily physical activity. This article focuses on the link between the metabolic capacity of skeletal muscle and the metabolic syndrome and briefly discusses the explanations for this relationship. As one important aspect if skeletal muscle has a high capacity for lipid oxidation, then more saturated fatty acids are oxidised and more unsaturated fatty acids are built in the phospholipid fraction of the plasma membrane, giving it more fluidity and improved insulin sensitivity. Moreover, the article points at the role of these fatty acids in activating genes via the PPAR-receptor system essential for enzyme and transport proteins in the lipid metabolism.
KW - Diabetes Mellitus, Type 2
KW - Energy Metabolism
KW - Exercise
KW - Humans
KW - Insulin Resistance
KW - Life Style
KW - Muscle, Skeletal
KW - Physical Endurance
KW - Physical Fitness
KW - Risk Factors
M3 - Tidsskriftartikel
C2 - 11149279
VL - 29
SP - 941
EP - 947
JO - Der Orthopade
JF - Der Orthopade
SN - 0085-4530
IS - 11
ER -
ID: 33862399