Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain

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  • Lasse Hartmann Schmidt
  • Jesper Stensig Aa
  • Hartmann, Bolette
  • Gunvor Iben Madsen
  • Niels Qvist
  • Mark Bremholm Ellebæk

Background: To investigate the effects of a reversed segment of the distal small intestine to improve weight gain in an experimental short bowel syndrome (SBS) model in piglets. Methods: Twenty-four piglets underwent resection of 70% of the distal small intestine. In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25 cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28. Results: The group with reversal of small intestine had a significant lower weight gain at 5.26 ± 3.39 kg (mean ± SD) compared to the control group with 11.14 ± 3.83 kg (p < 0.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group. Conclusions: Treatment of short bowel syndrome with a reversed jejunal segment of 25 cm had a detrimental effect on the weight gain.

TidsskriftBMC Gastroenterology
Udgave nummer1
Antal sider9
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
We wish to acknowledge the help provided by Pernille Simonsen, Diana Bianca Hansen, Stefanie Kolstrup and, Peter Bollen, Biomedical Laboratory, the University of Southern Denmark for technical assistance, and Jannie Kjær Buhl, Department of Pathology, Odense University Hospital, for help with histological preparation.

Funding Information:
This project is founded by the Danish Patient Society of Inflammatory Bowel Disease and Irritable Bowel Syndrome (Colitis Crohn Foreningen), The A.P. Møller Foundation for the Advancement of Medical Science (Grant No. 17-L-0090) and, Odense University Hospital Research Foundation (Grant No. R49-A2513). None of the funds had any influence in how the study was designed, and neither in collection, analysis, and interpretation of data or writing of the manuscript.

Publisher Copyright:
© 2022, The Author(s).

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