Repolarization Effects of sertindole manifest as T-wave flatness on the ECG
Publikation: Bidrag til tidsskrift › Konferenceartikel › Forskning › fagfællebedømt
Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.
Originalsprog | Engelsk |
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Artikelnummer | 7043059 |
Tidsskrift | Computing in Cardiology |
Vol/bind | 41 |
Sider (fra-til) | 381-384 |
ISSN | 2325-8861 |
Status | Udgivet - 1 jan. 2014 |
Begivenhed | 41st Computing in Cardiology Conference, CinC 2014 - Cambridge, USA Varighed: 7 sep. 2014 → 10 sep. 2014 |
Konference
Konference | 41st Computing in Cardiology Conference, CinC 2014 |
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Land | USA |
By | Cambridge |
Periode | 07/09/2014 → 10/09/2014 |
Sponsor | et al., IEEE/EMBS, Massachusetts Institute of Technology, Mortara, Philips, PhysioNet |
ID: 204298963