Quantification of lipoprotein profiles by nuclear magnetic resonance spectroscopy and multivariate data analysis

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Lipoproteins and their subfraction profiles have been associated to diverse diseases including Cardio Vascular Disease (CVD). There is thus a great demand for measuring and quantifying the lipoprotein profile in an efficient and accurate manner.
Nuclear Magnetic Resonance (NMR) spectroscopy is uniquely able to measure the lipoprotein profile of a blood sample non-destructively due to its sensitivity to both lipid chemistry and lipid-micellar physics. However, the NMR spectra must be scaled/regressed to a primary method of reference, such as ultracentrifugation,
using multivariate regression methods.
This review provides an overview of the field and explains the methods at stake.
TidsskriftTrends in Analytical Chemistry
Sider (fra-til)210-219
Antal sider10
StatusUdgivet - 2017

Bibliografisk note

CURIS 2017 NEXS 261

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