Outcome of limited-stage peripheral T-Cell lymphoma after CHOP(−like) therapy: A population based study of 239 patients from the Nordic lymphoma epidemiology group

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  • Ahmed Ludvigsen Al-Mashhadi
  • Henrik Cederleuf
  • Rasmus Kuhr Jensen
  • Torsten Holm Nielsen
  • Martin Bjerregård Pedersen
  • Thomas Bech Mortensen
  • Thomas Relander
  • Mats Jerkeman
  • Gang, Anne Ortved
  • Anne Louise Kristensen
  • Michael Roost Clausen
  • Brown, Peter de Nully
  • Marianne Tang Severinsen
  • Lasse Hjort Jakobsen
  • Fredrik Ellin
  • Tarec Christoffer El-Galaly

Peripheral T-Cell Lymphomas (PTCLs) are rare, aggressive lymphomas with poor outcomes, but limited-stage disease is infrequent and not well-described. This study reports outcomes and prognostic factors in limited-stage nodal PTCLs in a binational population-based setting. Patients were identified from the Danish and Swedish lymphoma registries. Adults diagnosed with limited-stage nodal PTCL (stage I-II) and treated with CHOP(−like) therapy ±radiotherapy between 2000 and 2014 were included. Medical records were reviewed by local investigators. A total of 239 patients with a median age of 62 years were included; 67% received 6–8 cycles of CHOP(−like) therapy and 22% received 3–4 cycles, of which 59% also received radiotherapy. Autologous stem cell transplant consolidation was administered to 16% of all patients. Median follow-up was 127 months with 5-years overall survival (OS) of 58% (95% CI: 53–65) and progression-free survival (PFS) of 53% (95% CI: 47–59). In multivariable analysis, age ≥ 60 years and B-symptoms were unfavorable and ALK+ anaplastic large cell T-Cell lymphoma was favorable for survival outcomes. There was no difference in treatment-specific outcome (3–4 cycles vs. 6–8 cycles of CHOP(−like) ± radiotherapy). Low-risk patients (age < 60 without B-symptoms) had a 5-year OS of 77% (95% CI 67–89%). In the present study of limited-stage nodal PTCL, survival after curative intent chemotherapy +/− radiotherapy was inferior to that of limited-stage diffuse large B-cell lymphoma, but a subgroup of young patients without B-symptoms had very good outcomes. Treatment outcomes after 3–4 cycles versus 6–8 cycles of CHOP(−like) therapy were comparable.

TidsskriftAmerican Journal of Hematology
Udgave nummer3
Sider (fra-til)388-397
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
This work was supported by the Danish Cancer Society [R321‐A17536, 2022] to [TCEG].

Funding Information:
TCEG reports unrelated previous employment by Roche Ltd, Basel and speaking fee from AbbVie. ALA reports unrelated research collaboration and funding from Genentech Inc.

Publisher Copyright:
© 2023 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.

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