MCT1 helps brown fat suck up succinate

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

TidsskriftNature Metabolism
Sider (fra-til)387–388
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
J. L. is supported by the BRIDGE – Translational Excellence Programme ( ) at the Faculty of Health and Medical Sciences, University of Copenhagen, funded by the Novo Nordisk Foundation (NNF20SA0064340). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research centre, based at the University of Copenhagen, and partially funded by an unconditional donation from the Novo Nordisk Foundation ( ; grant number NNF23SA0084103).

Publisher Copyright:
© Springer Nature Limited 2024.

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