Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men
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Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men. / Hashimoto, Takeshi; Tsukamoto, Hayato; Takenaka, Saki; Olesen, Niels D.; Petersen, Lonnie G.; Sørensen, Henrik; Nielsen, Henning B.; Secher, Niels H.; Ogoh, Shigehiko.
I: FASEB Journal, Bind 32, Nr. 3, 2018, s. 1417-1427.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men
AU - Hashimoto, Takeshi
AU - Tsukamoto, Hayato
AU - Takenaka, Saki
AU - Olesen, Niels D.
AU - Petersen, Lonnie G.
AU - Sørensen, Henrik
AU - Nielsen, Henning B.
AU - Secher, Niels H.
AU - Ogoh, Shigehiko
PY - 2018
Y1 - 2018
N2 - High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for the brain. This investigation examined whether improved EF after exercise relates to brain lactate uptake. Fourteen healthy, male subjects performed 2HIIEprotocols separatedby 60min of rest.Blood sampleswere obtained fromthe right internal jugular venous bulb and from the brachial artery to determine arterial-venous differences across the brain for lactate (a-v difflactate), glucose (a-v diffglucose), oxygen (a-v diffoxygen), and brain-derived neurotrophic factor (BDNF; a-v diffBDNF). EF was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a-v diffglucose was unchanged, whereas the a-v diffBDNF increased similarly after both HIIEs, and the a-v difflactate increased, but the increase was attenuated after the secondHIIE, compared with the firstHIIE (P < 0.05).The EF after HIIE correlatedwith the a-v difflactate (r2=0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.
AB - High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for the brain. This investigation examined whether improved EF after exercise relates to brain lactate uptake. Fourteen healthy, male subjects performed 2HIIEprotocols separatedby 60min of rest.Blood sampleswere obtained fromthe right internal jugular venous bulb and from the brachial artery to determine arterial-venous differences across the brain for lactate (a-v difflactate), glucose (a-v diffglucose), oxygen (a-v diffoxygen), and brain-derived neurotrophic factor (BDNF; a-v diffBDNF). EF was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a-v diffglucose was unchanged, whereas the a-v diffBDNF increased similarly after both HIIEs, and the a-v difflactate increased, but the increase was attenuated after the secondHIIE, compared with the firstHIIE (P < 0.05).The EF after HIIE correlatedwith the a-v difflactate (r2=0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.
KW - Brain energy uptake
KW - Brain-derived neurotrophic factor
KW - Cognitive function
KW - Glucose
KW - High-intensity interval exercise
U2 - 10.1096/fj.201700381RR
DO - 10.1096/fj.201700381RR
M3 - Journal article
C2 - 29127193
AN - SCOPUS:85036637181
VL - 32
SP - 1417
EP - 1427
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 3
ER -
ID: 214460065