Genetics may affect the risk of undergoing surgery for rhizarthrosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Osteoarthritis is a prevalent and severe disease. Involvement of the trapeziometacarpal joint is common and can lead to both pain and disability. Genetics are known to affect the risk of osteoarthritis, but it remains unclear how genetics affect disease trajectories. In this study, we investigated whether the genetic associations of trapeziometacarpal osteoarthritis (rhizarthrosis) vary with the need for surgical treatment. The study was conducted as a case-control genome-wide association study using individuals from the Copenhagen Hospital Biobank pain and degenerative musculoskeletal disease study and the Danish Blood Donor Study (N = 208,342). We identified patients diagnosed with rhizarthrosis and grouped them by treatment status, resulting in two case groups: surgical (N = 1083) and nonsurgical (N = 1888). The case groups were tested against osteoarthritis-free controls in two genome-wide association studies. We then compared variants suggestive of association (p < 10−6) in either of these analyses directly between the treatment groups (surgical vs. nonsurgical rhizarthrosis). We identified 10 variants suggestive of association with either surgical (seven variants) or nonsurgical (three variants) rhizarthrosis. None of the variants reached nominal significance in the opposite treatment group (p ≥ 0.14), and all 10 variants were significantly different between the treatment groups at a false discovery rate of 5%. These results suggest possible differences in the genetic associations of rhizarthrosis depending on surgical treatment. Clinical significance: Uncovering genetic differences between clinically distinct patient groups can reveal biological determinants of disease trajectories.
TidsskriftJournal of Orthopaedic Research
Udgave nummer5
Sider (fra-til)1001-1008
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
We wish to thank all the individuals who made this research possible, including both participants and personnel from the Danish Blood Donor Study and Copenhagen Hospital Biobank. The study was supported financially by the Candys Foundation (ref. no. 2019‐314), Greater Copenhagen Health Science Partners, and Copenhagen University Hospital Hvidovre. None of the funding sources had influence on the study design, the collection, analysis, or interpretation of data, writing of the manuscript, or the decision to submit the article for publication.

Publisher Copyright:
© 2023 Orthopaedic Research Society.

ID: 381725801