Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Standard
Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology. / Schnurr, Theresia Maria; Gjesing, Anette Marianne Prior; Sandholt, Camilla Helene; Jonsson, Anna Elisabet; Mahendran, Yuvaraj; Have, Christian Theil; Ekstrøm, Claus Thorn; Bjerregaard, Anne-Louise; Brage, Søren; Witte, Daniel; Jørgensen, Marit Eika; Aadahl, Mette; Thuesen, Betina Heinsbæk; Linneberg, Allan René; Eiberg, Hans Rudolf Lytchoff; Pedersen, Oluf Borbye; Grarup, Niels; Oskari Kilpeläinen, Tuomas; Hansen, Torben.
I: P L o S One, Bind 11, Nr. 11, e0166738, 15.11.2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology
AU - Schnurr, Theresia Maria
AU - Gjesing, Anette Marianne Prior
AU - Sandholt, Camilla Helene
AU - Jonsson, Anna Elisabet
AU - Mahendran, Yuvaraj
AU - Have, Christian Theil
AU - Ekstrøm, Claus Thorn
AU - Bjerregaard, Anne-Louise
AU - Brage, Søren
AU - Witte, Daniel
AU - Jørgensen, Marit Eika
AU - Aadahl, Mette
AU - Thuesen, Betina Heinsbæk
AU - Linneberg, Allan René
AU - Eiberg, Hans Rudolf Lytchoff
AU - Pedersen, Oluf Borbye
AU - Grarup, Niels
AU - Oskari Kilpeläinen, Tuomas
AU - Hansen, Torben
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Objectives: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF. Methods: Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition. Results: We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM. Conclusions: Our findings suggest a shared genetic etiology between whole body fat% and CRF.
AB - Objectives: It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF. Methods: Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyses, we examined two Danish population-based cohorts (ntotal = 3206). The body fat% GRS was created by summing the alleles of twelve independent risk variants known to associate with body fat%. We assessed CRF as maximal oxygen uptake expressed in millilitres of oxygen uptake per kg of body mass (VO2max), per kg fat-free mass (VO2maxFFM), or per kg fat mass (VO2maxFM). All analyses were adjusted for age and sex, and when relevant, for body composition. Results: We found a significant negative genetic correlation between VO2max and body fat% (ρG = -0.72 (SE ±0.13)). The body fat% GRS associated with decreased VO2max (β = -0.15 mL/kg/min per allele, p = 0.0034, age and sex adjusted). The body fat%-increasing FTO allele was associated with a 0.42 mL/kg/min unit decrease in VO2max per allele (p = 0.0092, age and sex adjusted). Both associations were abolished after additional adjustment for body fat%. The fat% increasing GRS and FTO risk allele were associated with decreased VO2maxFM but not with VO2maxFFM. Conclusions: Our findings suggest a shared genetic etiology between whole body fat% and CRF.
U2 - 10.1371/journal.pone.0166738
DO - 10.1371/journal.pone.0166738
M3 - Journal article
VL - 11
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - e0166738
ER -
ID: 169359873