Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study

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  • Marie Westergaard-Nielsen
  • Christian Godballe
  • Jesper Grau Eriksen
  • Stine Rosenkilde Larsen
  • Katalin Kiss
  • Tina Agander
  • Benedicte Parm Ulhøi
  • Charabi, Birgitte Wittenborg
  • Tejs Ehlers Klug
  • Henrik Jacobsen
  • Jørgen Johansen
  • Claus Andrup Kristensen
  • Elo Andersen
  • Maria Andersen
  • Kristine Bjørndal
The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.

All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.

The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11–102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.

The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.
TidsskriftEuropean Archives of Oto-Rhino-Laryngology
Udgave nummer7
Sider (fra-til)3405-3413
Antal sider9
StatusUdgivet - 2023

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