Elevated lipid class concentrations in females with anorexia nervosa before and after intensive weight restoration treatment—A lipidomics study

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  • Alia Arif Hussain
  • Mesut Bilgin
  • Jessica Carlsson
  • Mads Møller Foged
  • Mortensen, Erik Lykke
  • Cynthia M. Bulik
  • René Klinkby Støving
  • Jan Magnus Sjögren
To study the plasma lipidome of patients with anorexia nervosa (AN) before and after weight restoration treatment and report associations with AN subtypes and oral contraceptive pill (OCP) usage.

Quantitative shotgun lipidomics analysis was used to study plasma lipids of 50 female patients with AN before and after weight restoration treatment and 50 healthy female controls (HC). The AN group was assessed with blood samples and questionnaires before and after weight restoration.

In total we quantified 260 lipid species representing 26 lipid classes of which 13 lipid class concentrations were elevated in patients with AN at admission compared with HC. Lipid classes remained elevated after weight restoration treatment of 84 days (median; interquartile range 28), and only the concentration of the ceramide lipid class increased between pre- and post-treatment (p = .03), whereas lysophosphatidylcholine (LPC, p = .02), ether-linked Phosphatidylcholine (LPCO, p = .02), and lysophosphatidylethanolamine (LPE, p = .009) decreased.

In AN, 13 out of 26 lipid class concentrations were elevated at admission and remained elevated post-treatment. Ceramides increased further between pre- and post-weight restoration treatment, which could be related to the rapid weight gain during re-nutrition. Further research is needed to elucidate the effects of weight restoration treatment on short- and long-term lipid profiles in individuals with AN.
TidsskriftInternational Journal of Eating Disorders
Udgave nummer12
Sider (fra-til)2260-2272
Antal sider13
StatusUdgivet - 2023

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Publisher Copyright:
© 2023 The Authors. International Journal of Eating Disorders published by Wiley Periodicals LLC.

ID: 368502136