Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hetero Diels-Alder adducts. A rational for the observed enantioselectivity and conversion rate supported by computational calculations is provided.

TidsskriftJournal of Organic Chemistry
Udgave nummer11
Sider (fra-til)6940-6945
Antal sider6
StatusUdgivet - 7 jun. 2019

ID: 231361334