Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: Protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project

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  • Catherine Gibbons
  • Beverley O'Hara
  • Dominic O'Connor
  • Charlotte Hardman
  • Moon Wilton
  • Joanne A Harrold
  • Eva Almiron-Roig
  • Santiago Navas-Carretero
  • Charo E Hodgkins
  • Julie Anne Nazare
  • Maud Alligier
  • José Alfredo Martínez
  • Corey Scott
  • Mie Normand
  • Cécile Rannou
  • Ellen E Blaak
  • Edith Feskens
  • Hariklia Moshoyiannis
  • Jason C.G. Halford
  • Kristine Beaulieu
  • Graham Finlayson

Introduction: Intake of free sugars in European countries is high and attempts to reduce sugar intake have been mostly ineffective. Non-nutritive sweeteners and sweetness enhancers (S&SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&SEs and two S&SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes. 

Methods and analysis: A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). Participants (body mass index 25-35 kg/m2; aged 18-60 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14. 

Ethics and dissemination: The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive. 

Trial registration number: NCT04633681.

TidsskriftBMJ Open
Udgave nummer12
Antal sider9
StatusUdgivet - 2022

Bibliografisk note

CURIS 2022 NEXS 309
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 332046029