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Henrik Semb's research focus on elucidating basic mechanism in morphogenesis and how tissue architecture controls cell lineage commitment by using a combination of in vivo and in vitro genetic and cell biological experimental tools. Pancreas organogenesis in the mouse is used as model. We also use human pluripotent stem cells (hESCs/hiPSCs) as tools to study human pancreatic beta cell development and beta cell dysfunction in vitro as well as a source for transplantable beta cells in type 1 diabetes therapy.