Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

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Standard

Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. / Lehner, Michelle Harreman; Walker, Jane; Temcinaite, Kotryna; Herlihy, Anna; Taschner, Michael; Berger, Adam C.; Corbett, Anita H.; Dirac Svejstrup, A. Barbara; Svejstrup, Jesper Q.

I: Cell Reports, Bind 41, Nr. 4, 111536, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lehner, MH, Walker, J, Temcinaite, K, Herlihy, A, Taschner, M, Berger, AC, Corbett, AH, Dirac Svejstrup, AB & Svejstrup, JQ 2022, 'Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress', Cell Reports, bind 41, nr. 4, 111536. https://doi.org/10.1016/j.celrep.2022.111536

APA

Lehner, M. H., Walker, J., Temcinaite, K., Herlihy, A., Taschner, M., Berger, A. C., Corbett, A. H., Dirac Svejstrup, A. B., & Svejstrup, J. Q. (2022). Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Reports, 41(4), [111536]. https://doi.org/10.1016/j.celrep.2022.111536

Vancouver

Lehner MH, Walker J, Temcinaite K, Herlihy A, Taschner M, Berger AC o.a. Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. Cell Reports. 2022;41(4). 111536. https://doi.org/10.1016/j.celrep.2022.111536

Author

Lehner, Michelle Harreman ; Walker, Jane ; Temcinaite, Kotryna ; Herlihy, Anna ; Taschner, Michael ; Berger, Adam C. ; Corbett, Anita H. ; Dirac Svejstrup, A. Barbara ; Svejstrup, Jesper Q. / Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress. I: Cell Reports. 2022 ; Bind 41, Nr. 4.

Bibtex

@article{e05f28d5ef0b48049572add915bef231,
title = "Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress",
abstract = "The “last resort” pathway results in ubiquitylation and degradation of RNA polymerase II in response to transcription stress and is governed by factors such as Def1 in yeast. Here, we show that the SMY2 gene acts as a multi-copy suppressor of DEF1 deletion and functions at multiple steps of the last resort pathway. We also provide genetic and biochemical evidence from disparate cellular processes that Smy2 works more broadly as a hitherto overlooked regulator of Cdc48 function. Similarly, the Smy2 homologs GIGYF1 and -2 affect the transcription stress response in human cells and regulate the function of the Cdc48 homolog VCP/p97, presently being explored as a target for cancer therapy. Indeed, we show that the apoptosis-inducing effect of VCP inhibitors NMS-873 and CB-5083 is GIGYF1/2 dependent.",
keywords = "cdc48, CP: Molecular biology, DEF1, GIGYF1, GIGYF2, last resort pathway, p97, proteasome, RNA polymerase II, SMY2, VCP",
author = "Lehner, {Michelle Harreman} and Jane Walker and Kotryna Temcinaite and Anna Herlihy and Michael Taschner and Berger, {Adam C.} and Corbett, {Anita H.} and {Dirac Svejstrup}, {A. Barbara} and Svejstrup, {Jesper Q.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
doi = "10.1016/j.celrep.2022.111536",
language = "English",
volume = "41",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress

AU - Lehner, Michelle Harreman

AU - Walker, Jane

AU - Temcinaite, Kotryna

AU - Herlihy, Anna

AU - Taschner, Michael

AU - Berger, Adam C.

AU - Corbett, Anita H.

AU - Dirac Svejstrup, A. Barbara

AU - Svejstrup, Jesper Q.

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022

Y1 - 2022

N2 - The “last resort” pathway results in ubiquitylation and degradation of RNA polymerase II in response to transcription stress and is governed by factors such as Def1 in yeast. Here, we show that the SMY2 gene acts as a multi-copy suppressor of DEF1 deletion and functions at multiple steps of the last resort pathway. We also provide genetic and biochemical evidence from disparate cellular processes that Smy2 works more broadly as a hitherto overlooked regulator of Cdc48 function. Similarly, the Smy2 homologs GIGYF1 and -2 affect the transcription stress response in human cells and regulate the function of the Cdc48 homolog VCP/p97, presently being explored as a target for cancer therapy. Indeed, we show that the apoptosis-inducing effect of VCP inhibitors NMS-873 and CB-5083 is GIGYF1/2 dependent.

AB - The “last resort” pathway results in ubiquitylation and degradation of RNA polymerase II in response to transcription stress and is governed by factors such as Def1 in yeast. Here, we show that the SMY2 gene acts as a multi-copy suppressor of DEF1 deletion and functions at multiple steps of the last resort pathway. We also provide genetic and biochemical evidence from disparate cellular processes that Smy2 works more broadly as a hitherto overlooked regulator of Cdc48 function. Similarly, the Smy2 homologs GIGYF1 and -2 affect the transcription stress response in human cells and regulate the function of the Cdc48 homolog VCP/p97, presently being explored as a target for cancer therapy. Indeed, we show that the apoptosis-inducing effect of VCP inhibitors NMS-873 and CB-5083 is GIGYF1/2 dependent.

KW - cdc48

KW - CP: Molecular biology

KW - DEF1

KW - GIGYF1

KW - GIGYF2

KW - last resort pathway

KW - p97

KW - proteasome

KW - RNA polymerase II

KW - SMY2

KW - VCP

U2 - 10.1016/j.celrep.2022.111536

DO - 10.1016/j.celrep.2022.111536

M3 - Journal article

C2 - 36288698

AN - SCOPUS:85140294655

VL - 41

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 4

M1 - 111536

ER -

ID: 324315935