Whole body periodic acceleration improves muscle recovery after eccentric exercise
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Whole body periodic acceleration improves muscle recovery after eccentric exercise. / López, José Rafael; Mijares, Alfredo; Kolster, Juan; Henríquez-Olguín, Carlos; Zhang, Rui; Altamirano, Francisco; Adams, José Antonio.
I: Medicine and Science in Sports and Exercise, Bind 48, Nr. 8, 2016, s. 1485-1494.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Whole body periodic acceleration improves muscle recovery after eccentric exercise
AU - López, José Rafael
AU - Mijares, Alfredo
AU - Kolster, Juan
AU - Henríquez-Olguín, Carlos
AU - Zhang, Rui
AU - Altamirano, Francisco
AU - Adams, José Antonio
N1 - Publisher Copyright: Copyright © 2016 by the American College of Sports Medicine.
PY - 2016
Y1 - 2016
N2 - Introduction: The aim of this study was to determine whether whole body periodic acceleration (pGz) could improve muscle recovery after unaccustomed eccentric exercise (EE). Methods: Downhill treadmill running was used to elicit EE-induced muscle damage in mice, and pGz treatment (480 cycles per minute, 1 h·d -1) was applied daily for 10 d after the initial EE bout (day 0). Every 2 d during the pGz treatment course starting at day 0, we 1) assessed intracellular Ca 2+ and Na + concentrations and membrane potential (as indicators of intracellular ion dysfunction) in vivo in gastrocnemius muscle from anesthetized animals and 2) quantified creatine kinase (CK), tumor necrosis factor α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations in plasma or muscle lysates (as indicators of muscle damage and inflammation). Results: EE significantly increased intracellular Ca 2+ and Na +, CK, TNF-α, MCP-1, IL-6, and IL-10, all of which peaked on day 2 with the exception of IL-10 and declined slowly over 10 d of recovery. pGz treatment after the EE bout mitigated ion dyshomeostasis and expedited recuperation to control values after 6 d of treatment. pGz treatment also accelerated the normalization of CK, TNF-α, MCP-1, and IL-6 while further increasing IL-10 concentrations. The nitric oxide synthase inhibitor L-N G -nitroarginine methyl ester, administered in drinking water before and maintained throughout the treatment course, was sufficient to abrogate the salutary effects of pGz after EE. Conclusions: The present study demonstrates whole body periodic acceleration as an effective therapeutic strategy to accelerate muscle recovery after EE-induced skeletal muscle injury, as indicated by a faster normalization of all the studied parameters.
AB - Introduction: The aim of this study was to determine whether whole body periodic acceleration (pGz) could improve muscle recovery after unaccustomed eccentric exercise (EE). Methods: Downhill treadmill running was used to elicit EE-induced muscle damage in mice, and pGz treatment (480 cycles per minute, 1 h·d -1) was applied daily for 10 d after the initial EE bout (day 0). Every 2 d during the pGz treatment course starting at day 0, we 1) assessed intracellular Ca 2+ and Na + concentrations and membrane potential (as indicators of intracellular ion dysfunction) in vivo in gastrocnemius muscle from anesthetized animals and 2) quantified creatine kinase (CK), tumor necrosis factor α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations in plasma or muscle lysates (as indicators of muscle damage and inflammation). Results: EE significantly increased intracellular Ca 2+ and Na +, CK, TNF-α, MCP-1, IL-6, and IL-10, all of which peaked on day 2 with the exception of IL-10 and declined slowly over 10 d of recovery. pGz treatment after the EE bout mitigated ion dyshomeostasis and expedited recuperation to control values after 6 d of treatment. pGz treatment also accelerated the normalization of CK, TNF-α, MCP-1, and IL-6 while further increasing IL-10 concentrations. The nitric oxide synthase inhibitor L-N G -nitroarginine methyl ester, administered in drinking water before and maintained throughout the treatment course, was sufficient to abrogate the salutary effects of pGz after EE. Conclusions: The present study demonstrates whole body periodic acceleration as an effective therapeutic strategy to accelerate muscle recovery after EE-induced skeletal muscle injury, as indicated by a faster normalization of all the studied parameters.
KW - Calcium overload
KW - Muscle damage
KW - Nitric oxide
KW - Proinflammatory cytokines
KW - Sodium overload
UR - http://www.scopus.com/inward/record.url?scp=84962052547&partnerID=8YFLogxK
U2 - 10.1249/MSS.0000000000000932
DO - 10.1249/MSS.0000000000000932
M3 - Journal article
C2 - 27031739
AN - SCOPUS:84962052547
VL - 48
SP - 1485
EP - 1494
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 8
ER -
ID: 306300556