White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging
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Age-related dopamine reductions have been suggested to contribute to maladaptive working memory (WM) function in older ages. One promising intervention approach is to increase physical activity, as this has been associated with plasticity of the striatal dopamine system and WM improvements, however with individual differences in efficacy. The present work focused on the impact of individual differences in white-matter lesion burden upon dopamine D2-like receptor (DRD2) availability and WM changes in response to a 6 months physical activity intervention. While the intervention altered striatal DRD2 availability and WM performance in individuals with no or only mild lesions (p < 0.05), no such effects were found in individuals with moderate-to-severe lesion severity (p > 0.05). Follow-up analyses revealed a similar pattern for processing speed, but not for episodic memory performance. Linear analyses further revealed that lesion volume (ml) at baseline was associated with reduced DRD2 availability (r = −0.41, p < 0.05), and level of DRD2 change (r = 0.40, p < 0.05). Taken together, this study underlines the necessity to consider cerebrovascular health in interventions with neurocognitive targets. Future work should assess whether these findings extend beyond measures of DRD2 availability and WM.
Originalsprog | Engelsk |
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Artikelnummer | 28 |
Tidsskrift | Translational Psychiatry |
Vol/bind | 13 |
ISSN | 2158-3188 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This work was funded by grants from the Swedish Research Council (2012-00530), Västerbotten County Council and Umeå University, the Swedish Research Council for Sport Science and Umeå School of Sport Sciences, the Kamprad Family Foundation, and the Swedish Brain Foundation. The FreeSurfer analyses were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) at HPC2N in Umeå. We thank Professor Lars Nyberg for comments on earlier drafts.
Publisher Copyright:
© 2023, The Author(s).
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