Voltage fluctuations in neurons: signal or noise?
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Voltage fluctuations in neurons: signal or noise? / Yarom, Yosef; Hounsgaard, Jorn.
I: Physiological Reviews, Bind 91, Nr. 3, 01.07.2011, s. 917-29.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Voltage fluctuations in neurons: signal or noise?
AU - Yarom, Yosef
AU - Hounsgaard, Jorn
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Noise and variability are fundamental companions to ion channels and synapses and thus inescapable elements of brain function. The overriding unresolved issue is to what extent noise distorts and limits signaling on one hand and at the same time constitutes a crucial and fundamental enrichment that allows and facilitates complex adaptive behavior in an unpredictable world. Here we review the growing experimental evidence that functional network activity is associated with intense fluctuations in membrane potential and spike timing. We trace origins and consequences of noise and variability. Finally, we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues for future studies.
AB - Noise and variability are fundamental companions to ion channels and synapses and thus inescapable elements of brain function. The overriding unresolved issue is to what extent noise distorts and limits signaling on one hand and at the same time constitutes a crucial and fundamental enrichment that allows and facilitates complex adaptive behavior in an unpredictable world. Here we review the growing experimental evidence that functional network activity is associated with intense fluctuations in membrane potential and spike timing. We trace origins and consequences of noise and variability. Finally, we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues for future studies.
U2 - 10.1152/physrev.00019.2010
DO - 10.1152/physrev.00019.2010
M3 - Journal article
C2 - 21742791
VL - 91
SP - 917
EP - 929
JO - Physiological Reviews
JF - Physiological Reviews
SN - 0031-9333
IS - 3
ER -
ID: 33757074