TY - JOUR

T1 - Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation

AU - Gjaerde, Lars Klingen

AU - Ostrowski, Sisse Rye

AU - Minculescu, Lia

AU - Andersen, Niels Smedegaard

AU - Friis, Lone Smidstrup

AU - Kornblit, Brian

AU - Petersen, Soren Lykke

AU - Schjodt, Ida

AU - Sengelov, Henrik

PY - 2021

Y1 - 2021

N2 - Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD.Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days).Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD.Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.

AB - Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD.Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days).Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD.Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.

KW - acute graft&#8208

KW - versus&#8208

KW - host disease

KW - allogeneic hematopoietic cell transplantation

KW - vitamin E

KW - T-HELPER-1 CYTOKINE PRODUCTION

KW - HIGH-DOSE CHEMOTHERAPY

KW - ALPHA-TOCOPHEROL

KW - ANTIOXIDANT STATUS

KW - PLASMA

KW - SUPPLEMENTATION

KW - ADHESION

KW - RECIPIENTS

KW - MUCOSITIS

U2 - 10.1111/ejh.13567

DO - 10.1111/ejh.13567

M3 - Journal article

C2 - 33314420

VL - 106

SP - 417

EP - 424

JO - European Journal of Haematology

JF - European Journal of Haematology

SN - 0902-4441

IS - 3

ER -