Vertebral bone marrow (Modic) changes
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Vertebral bone marrow (Modic) changes. / Määttä, Juhani; Jensen, Tue Secher; Udby, Peter M.; Barajas, J. Nicolás; Samartzis, Dino; Niinimäki, Jaakko; Karppinen, Jaro I.
Spine Phenotypes. Academic Press, 2022. s. 223-252.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Vertebral bone marrow (Modic) changes
AU - Määttä, Juhani
AU - Jensen, Tue Secher
AU - Udby, Peter M.
AU - Barajas, J. Nicolás
AU - Samartzis, Dino
AU - Niinimäki, Jaakko
AU - Karppinen, Jaro I.
N1 - Publisher Copyright: © 2022 Elsevier Inc. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Modic changes (MCs) are bone marrow changes in the spine, and they are classified into three categories (types 1, 2, and 3) based on magnetic resonance imaging (MRI) appearance. They share several determinants with bone marrow changes at other sites of the body. The precise pathology of MCs is still unclear but includes structural disc damage and the inflammatory response to it, atypical mechanical loading, and possible bacterial etiology. In particular, Modic type 1 change (MC1) is thought to be associated with low back pain (LBP) but may also occur among the normal, asymptomatic population. However, MC1 may play a role, especially among patients with chronic, troublesome LBP. Clinically, MCs are diagnosed using MRI with no evident clinical tests or diagnostic algorithms. Unfortunately, no evidence-based treatment options exist yet for patients with pain and MCs although fusion surgery, antibiotic, and nerve ablation treatment are being explored. Overall, MCs are clinically important structural spine phenotypes, with varied etiology and prognostics and a need for refined classification.
AB - Modic changes (MCs) are bone marrow changes in the spine, and they are classified into three categories (types 1, 2, and 3) based on magnetic resonance imaging (MRI) appearance. They share several determinants with bone marrow changes at other sites of the body. The precise pathology of MCs is still unclear but includes structural disc damage and the inflammatory response to it, atypical mechanical loading, and possible bacterial etiology. In particular, Modic type 1 change (MC1) is thought to be associated with low back pain (LBP) but may also occur among the normal, asymptomatic population. However, MC1 may play a role, especially among patients with chronic, troublesome LBP. Clinically, MCs are diagnosed using MRI with no evident clinical tests or diagnostic algorithms. Unfortunately, no evidence-based treatment options exist yet for patients with pain and MCs although fusion surgery, antibiotic, and nerve ablation treatment are being explored. Overall, MCs are clinically important structural spine phenotypes, with varied etiology and prognostics and a need for refined classification.
KW - Bone marrow edema
KW - Endplate changes
KW - Modic changes
KW - Subchondral bone marrow
KW - Vertebral bone marrow
U2 - 10.1016/B978-0-12-822778-7.00019-5
DO - 10.1016/B978-0-12-822778-7.00019-5
M3 - Book chapter
AN - SCOPUS:85142583248
SN - 9780128227794
SP - 223
EP - 252
BT - Spine Phenotypes
PB - Academic Press
ER -
ID: 335696096