Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

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Standard

Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis. / Hedges, Emily P.; Dickson, Hannah; Tognin, Stefania; Modinos, Gemma; Antoniades, Mathilde; van der Gaag, Mark; de Haan, Lieuwe; McGorry, Patrick; Pantelis, Christos; Riecher-Rössler, Anita; Bressan, Rodrigo; Barrantes-Vidal, Neus; Krebs, Marie Odile; Nordentoft, Merete; Ruhrmann, Stephan; Sachs, Gabriele; Rutten, Bart P.; van Os, Jim; Valmaggia, Lucia R.; McGuire, Philip; Kempton, Matthew J.; EU-GEI High Risk Study.

I: Schizophrenia Research: Cognition, Bind 28, 100222, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hedges, EP, Dickson, H, Tognin, S, Modinos, G, Antoniades, M, van der Gaag, M, de Haan, L, McGorry, P, Pantelis, C, Riecher-Rössler, A, Bressan, R, Barrantes-Vidal, N, Krebs, MO, Nordentoft, M, Ruhrmann, S, Sachs, G, Rutten, BP, van Os, J, Valmaggia, LR, McGuire, P, Kempton, MJ & EU-GEI High Risk Study 2022, 'Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis', Schizophrenia Research: Cognition, bind 28, 100222. https://doi.org/10.1016/j.scog.2021.100222

APA

Hedges, E. P., Dickson, H., Tognin, S., Modinos, G., Antoniades, M., van der Gaag, M., de Haan, L., McGorry, P., Pantelis, C., Riecher-Rössler, A., Bressan, R., Barrantes-Vidal, N., Krebs, M. O., Nordentoft, M., Ruhrmann, S., Sachs, G., Rutten, B. P., van Os, J., Valmaggia, L. R., ... EU-GEI High Risk Study (2022). Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis. Schizophrenia Research: Cognition, 28, [100222]. https://doi.org/10.1016/j.scog.2021.100222

Vancouver

Hedges EP, Dickson H, Tognin S, Modinos G, Antoniades M, van der Gaag M o.a. Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis. Schizophrenia Research: Cognition. 2022;28. 100222. https://doi.org/10.1016/j.scog.2021.100222

Author

Hedges, Emily P. ; Dickson, Hannah ; Tognin, Stefania ; Modinos, Gemma ; Antoniades, Mathilde ; van der Gaag, Mark ; de Haan, Lieuwe ; McGorry, Patrick ; Pantelis, Christos ; Riecher-Rössler, Anita ; Bressan, Rodrigo ; Barrantes-Vidal, Neus ; Krebs, Marie Odile ; Nordentoft, Merete ; Ruhrmann, Stephan ; Sachs, Gabriele ; Rutten, Bart P. ; van Os, Jim ; Valmaggia, Lucia R. ; McGuire, Philip ; Kempton, Matthew J. ; EU-GEI High Risk Study. / Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis. I: Schizophrenia Research: Cognition. 2022 ; Bind 28.

Bibtex

@article{38b3cb20d3f849718838d4afe7ff0dae,

title = "Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis",

abstract = "Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.",

keywords = "Cognition, Early intervention, Prodrome, Transition, Verbal fluency",

author = "Hedges, {Emily P.} and Hannah Dickson and Stefania Tognin and Gemma Modinos and Mathilde Antoniades and {van der Gaag}, Mark and {de Haan}, Lieuwe and Patrick McGorry and Christos Pantelis and Anita Riecher-R{\"o}ssler and Rodrigo Bressan and Neus Barrantes-Vidal and Krebs, {Marie Odile} and Merete Nordentoft and Stephan Ruhrmann and Gabriele Sachs and Rutten, {Bart P.} and {van Os}, Jim and Valmaggia, {Lucia R.} and Philip McGuire and Kempton, {Matthew J.} and {EU-GEI High Risk Study}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

doi = "10.1016/j.scog.2021.100222",

language = "English",

volume = "28",

journal = "Schizophrenia Research: Cognition",

issn = "2215-0013",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

AU - Hedges, Emily P.

AU - Dickson, Hannah

AU - Tognin, Stefania

AU - Modinos, Gemma

AU - Antoniades, Mathilde

AU - van der Gaag, Mark

AU - de Haan, Lieuwe

AU - McGorry, Patrick

AU - Pantelis, Christos

AU - Riecher-Rössler, Anita

AU - Bressan, Rodrigo

AU - Barrantes-Vidal, Neus

AU - Krebs, Marie Odile

AU - Nordentoft, Merete

AU - Ruhrmann, Stephan

AU - Sachs, Gabriele

AU - Rutten, Bart P.

AU - van Os, Jim

AU - Valmaggia, Lucia R.

AU - McGuire, Philip

AU - Kempton, Matthew J.

AU - EU-GEI High Risk Study

PY - 2022

Y1 - 2022

N2 - Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.

AB - Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.

KW - Cognition

KW - Early intervention

KW - Prodrome

KW - Transition

KW - Verbal fluency

U2 - 10.1016/j.scog.2021.100222

DO - 10.1016/j.scog.2021.100222

M3 - Journal article

C2 - 35242602

AN - SCOPUS:85123895959

VL - 28

JO - Schizophrenia Research: Cognition

JF - Schizophrenia Research: Cognition

SN - 2215-0013

M1 - 100222

ER -

ID: 313678296