Variable ATP yields and uncoupling of oxygen consumption in human brain
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Variable ATP yields and uncoupling of oxygen consumption in human brain. / Gjedde, Albert; Aanerud, Joel; Peterson, Ericka; Ashkanian, Mahmoud; Iversen, Peter; Vafaee, Manoucher; Møller, Peter Arne; Borghammer, Per.
I: Advances in Experimental Medicine and Biology, Bind 701, 2011, s. 243-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Variable ATP yields and uncoupling of oxygen consumption in human brain
AU - Gjedde, Albert
AU - Aanerud, Joel
AU - Peterson, Ericka
AU - Ashkanian, Mahmoud
AU - Iversen, Peter
AU - Vafaee, Manoucher
AU - Møller, Peter Arne
AU - Borghammer, Per
PY - 2011
Y1 - 2011
N2 - The distribution of brain oxidative metabolism values among healthy humans is astoundingly wide for a measure that reflects normal brain function and is known to change very little with most changes of brain function. It is possible that the part of the oxygen consumption rate that is coupled to ATP turnover is the same in all healthy human brains, with different degrees of uncoupling explaining the variability of total oxygen consumption among people. To test the hypothesis that about 75% of the average total oxygen consumption of human brains is common to all individuals, we determined the variability in a large group of normal healthy adults. To establish the degree of variability in different regions of the brain, we measured the regional cerebral metabolic rate for oxygen in 50 healthy volunteers aged 21-66 and projected the values to a common age of 25.Within each subject and region, we normalized the metabolic rate to the population average of that region. Coefficients of variation ranged from 10 to 15% in the different regions of the human brain and the normalized regional metabolic rates ranged from 70% to 140% of the population average for each region, equal to a two-fold variation. Thus the hypothetical threshold of oxygen metabolism coupled to ATP turnover in all subjects is no more than 70% of the average oxygen consumption of that population.
AB - The distribution of brain oxidative metabolism values among healthy humans is astoundingly wide for a measure that reflects normal brain function and is known to change very little with most changes of brain function. It is possible that the part of the oxygen consumption rate that is coupled to ATP turnover is the same in all healthy human brains, with different degrees of uncoupling explaining the variability of total oxygen consumption among people. To test the hypothesis that about 75% of the average total oxygen consumption of human brains is common to all individuals, we determined the variability in a large group of normal healthy adults. To establish the degree of variability in different regions of the brain, we measured the regional cerebral metabolic rate for oxygen in 50 healthy volunteers aged 21-66 and projected the values to a common age of 25.Within each subject and region, we normalized the metabolic rate to the population average of that region. Coefficients of variation ranged from 10 to 15% in the different regions of the human brain and the normalized regional metabolic rates ranged from 70% to 140% of the population average for each region, equal to a two-fold variation. Thus the hypothetical threshold of oxygen metabolism coupled to ATP turnover in all subjects is no more than 70% of the average oxygen consumption of that population.
KW - Adenosine Triphosphate
KW - Adult
KW - Aged
KW - Brain
KW - Humans
KW - Magnetic Resonance Imaging
KW - Middle Aged
KW - Oxygen
KW - Oxygen Consumption
KW - Positron-Emission Tomography
KW - Young Adult
U2 - 10.1007/978-1-4419-7756-4_32
DO - 10.1007/978-1-4419-7756-4_32
M3 - Journal article
C2 - 21445793
VL - 701
SP - 243
EP - 248
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -
ID: 44913840