Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers
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Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers. / Bruun, C. S.; Bank, A.; Ström, A.; Proschowsky, H. F.; Fredholm, M.
I: Animal Genetics, Bind 51, Nr. 4, 2020, s. 617-619.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Validation of DNA test for hip dysplasia failed in Danish Labrador Retrievers
AU - Bruun, C. S.
AU - Bank, A.
AU - Ström, A.
AU - Proschowsky, H. F.
AU - Fredholm, M.
PY - 2020
Y1 - 2020
N2 - Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.
AB - Canine hip dysplasia is characterized by poor hip joint conformation and laxity. The disease is a complex trait influenced by both genetics and environment. Diagnosis and quantification of hip dysplasia are performed by radiographic examination of the hip joint and the diagnosis is used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed in a study based on Spanish Labrador Retrievers. In our study this test has been evaluated in 39 Danish Labrador Retrievers with known radiographic hip score: 14 with hip dysplasia (grade D or E) and 25 without hip dysplasia (grade A or B). There was no significant correlation between the Dysgen test results and the radiographic hip status (P = 0.3203) in these dogs, indicating that Dysgen test results obtained for Danish Labrador Retrievers have no prognostic value.
KW - canine hip dysplasia
KW - genotyping
U2 - 10.1111/age.12951
DO - 10.1111/age.12951
M3 - Journal article
C2 - 32432791
AN - SCOPUS:85085012784
VL - 51
SP - 617
EP - 619
JO - Animal Genetics
JF - Animal Genetics
SN - 0268-9146
IS - 4
ER -
ID: 242782214