Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia
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Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia. / Nielsen, T Rune; Segers, Kurt; Vanderaspoilden, Valérie; Beinhoff, Ulrike; Minthon, Lennart; Pissiota, Anna; Bekkhus-Wetterberg, Peter; Bjørkløf, Guro Hanevold; Tsolaki, Magda; Gkioka, Mara; Waldemar, Gunhild.
I: International Journal of Geriatric Psychiatry, Bind 34, Nr. 1, 01.2019, s. 144-152.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia
AU - Nielsen, T Rune
AU - Segers, Kurt
AU - Vanderaspoilden, Valérie
AU - Beinhoff, Ulrike
AU - Minthon, Lennart
AU - Pissiota, Anna
AU - Bekkhus-Wetterberg, Peter
AU - Bjørkløf, Guro Hanevold
AU - Tsolaki, Magda
AU - Gkioka, Mara
AU - Waldemar, Gunhild
N1 - © 2018 John Wiley & Sons, Ltd.
PY - 2019/1
Y1 - 2019/1
N2 - BACKGROUND: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties.METHODS: The study was a Western European cross-sectional multi-center study. A total of 66 patients with dementia and 118 cognitively intact participants were included across six memory clinics; 93 had ethnic minority background and 91 had ethnic majority background. Tests in the CNTB cover global cognitive function, memory, language, executive functions, and visuospatial functions.RESULTS: Significant differences with moderate to large effect sizes were present between patients with dementia and control participants on all CNTB measures. Area under the curves (AUC) ranged from .62 to .99 with a mean AUC across all measures of .83. Comparison of ethnic minority and majority groups generally revealed higher sensitivity in the minority group but no significant difference in the mean AUC's across all measures (.84 vs78, P = .42). Comparison of impairment profiles for patients with Alzheimer's disease (AD) and non-AD dementia revealed that AD patients were significantly more impaired on the memory domain, whereas patients with non-AD dementia were more impaired on the executive functions domain.CONCLUSIONS: The CNTB was found to have promising cross-cultural diagnostic properties for evaluation of dementia in the targeted minority and majority populations and could represent a valid cross-cultural alternative to other well-established neuropsychological test batteries when assessing patients from these populations.
AB - BACKGROUND: The aims of this study were to establish the diagnostic accuracy of the European Cross-Cultural Neuropsychological Test Battery (CNTB) for dementia in different ethnic populations in Western Europe, to examine its ability to differentiate cognitive impairment profiles for dementia subtypes, and to assess the impact of demographic variables on diagnostic properties.METHODS: The study was a Western European cross-sectional multi-center study. A total of 66 patients with dementia and 118 cognitively intact participants were included across six memory clinics; 93 had ethnic minority background and 91 had ethnic majority background. Tests in the CNTB cover global cognitive function, memory, language, executive functions, and visuospatial functions.RESULTS: Significant differences with moderate to large effect sizes were present between patients with dementia and control participants on all CNTB measures. Area under the curves (AUC) ranged from .62 to .99 with a mean AUC across all measures of .83. Comparison of ethnic minority and majority groups generally revealed higher sensitivity in the minority group but no significant difference in the mean AUC's across all measures (.84 vs78, P = .42). Comparison of impairment profiles for patients with Alzheimer's disease (AD) and non-AD dementia revealed that AD patients were significantly more impaired on the memory domain, whereas patients with non-AD dementia were more impaired on the executive functions domain.CONCLUSIONS: The CNTB was found to have promising cross-cultural diagnostic properties for evaluation of dementia in the targeted minority and majority populations and could represent a valid cross-cultural alternative to other well-established neuropsychological test batteries when assessing patients from these populations.
KW - Aged
KW - Aged, 80 and over
KW - Alzheimer Disease/psychology
KW - Area Under Curve
KW - Cognition
KW - Cognitive Dysfunction/diagnosis
KW - Cross-Cultural Comparison
KW - Cross-Sectional Studies
KW - Dementia/diagnosis
KW - Ethnic Groups
KW - Europe
KW - Executive Function
KW - Female
KW - Humans
KW - Language
KW - Male
KW - Memory
KW - Middle Aged
KW - Neuropsychological Tests/standards
U2 - 10.1002/gps.5002
DO - 10.1002/gps.5002
M3 - Journal article
C2 - 30246268
VL - 34
SP - 144
EP - 152
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 1
ER -
ID: 235003687