UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

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Standard

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. / Williamson, L; Saponaro, M; Boeing, S; East, P; Mitter, R; Kantidakis, T; Kelly, GP; Lobley, A; Walker, J; Spencer-Dene, B; Howell, M; Stewart, A; Svejstrup, JQ.

I: Cell, Bind 168, Nr. 5, 2017, s. 843-855.e13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Williamson, L, Saponaro, M, Boeing, S, East, P, Mitter, R, Kantidakis, T, Kelly, GP, Lobley, A, Walker, J, Spencer-Dene, B, Howell, M, Stewart, A & Svejstrup, JQ 2017, 'UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.', Cell, bind 168, nr. 5, s. 843-855.e13. https://doi.org/10.1016/j.cell.2017.01.019

APA

Williamson, L., Saponaro, M., Boeing, S., East, P., Mitter, R., Kantidakis, T., Kelly, GP., Lobley, A., Walker, J., Spencer-Dene, B., Howell, M., Stewart, A., & Svejstrup, JQ. (2017). UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. Cell, 168(5), 843-855.e13. https://doi.org/10.1016/j.cell.2017.01.019

Vancouver

Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T o.a. UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. Cell. 2017;168(5):843-855.e13. https://doi.org/10.1016/j.cell.2017.01.019

Author

Williamson, L ; Saponaro, M ; Boeing, S ; East, P ; Mitter, R ; Kantidakis, T ; Kelly, GP ; Lobley, A ; Walker, J ; Spencer-Dene, B ; Howell, M ; Stewart, A ; Svejstrup, JQ. / UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. I: Cell. 2017 ; Bind 168, Nr. 5. s. 843-855.e13.

Bibtex

@article{cbe5bfc0191f456faac8e366b0ac4135,

title = "UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.",

abstract = "The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ∼25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons (ALEs) that are more proximal to the transcription start site. Notably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription. The non-coding ASCC3 isoform counteracts the function of the protein-coding isoform, indicating crosstalk between them. Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage.",

author = "L Williamson and M Saponaro and S Boeing and P East and R Mitter and T Kantidakis and GP Kelly and A Lobley and J Walker and B Spencer-Dene and M Howell and A Stewart and JQ Svejstrup",

year = "2017",

doi = "10.1016/j.cell.2017.01.019",

language = "English",

volume = "168",

pages = "843--855.e13",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

AU - Williamson, L

AU - Saponaro, M

AU - Boeing, S

AU - East, P

AU - Mitter, R

AU - Kantidakis, T

AU - Kelly, GP

AU - Lobley, A

AU - Walker, J

AU - Spencer-Dene, B

AU - Howell, M

AU - Stewart, A

AU - Svejstrup, JQ

PY - 2017

Y1 - 2017

N2 - The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ∼25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons (ALEs) that are more proximal to the transcription start site. Notably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription. The non-coding ASCC3 isoform counteracts the function of the protein-coding isoform, indicating crosstalk between them. Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage.

AB - The transcription-related DNA damage response was analyzed on a genome-wide scale with great spatial and temporal resolution. Upon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promoter-proximal ∼25 kb is observed. This is associated with a shift from expression of long mRNAs to shorter isoforms, incorporating alternative last exons (ALEs) that are more proximal to the transcription start site. Notably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery of transcription. The non-coding ASCC3 isoform counteracts the function of the protein-coding isoform, indicating crosstalk between them. Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage.

U2 - 10.1016/j.cell.2017.01.019

DO - 10.1016/j.cell.2017.01.019

M3 - Journal article

C2 - 28215706

VL - 168

SP - 843-855.e13

JO - Cell

JF - Cell

SN - 0092-8674

IS - 5

ER -

ID: 331083390