Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction. / Mohammad, Moman A.; Koul, Sasha; Egerstedt, Anna; Smith, J. Gustav; Noc, Marko; Lang, Irene; Holzer, Michael; Clemmensen, Peter; Gidlöf, Olof; Metzler, Bernhard; Engstrøm, Thomas; Erlinge, David.

I: Scientific Reports, Bind 10, Nr. 1, 18663, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mohammad, MA, Koul, S, Egerstedt, A, Smith, JG, Noc, M, Lang, I, Holzer, M, Clemmensen, P, Gidlöf, O, Metzler, B, Engstrøm, T & Erlinge, D 2020, 'Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction', Scientific Reports, bind 10, nr. 1, 18663. https://doi.org/10.1038/s41598-020-75399-6

APA

Mohammad, M. A., Koul, S., Egerstedt, A., Smith, J. G., Noc, M., Lang, I., Holzer, M., Clemmensen, P., Gidlöf, O., Metzler, B., Engstrøm, T., & Erlinge, D. (2020). Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction. Scientific Reports, 10(1), [18663]. https://doi.org/10.1038/s41598-020-75399-6

Vancouver

Mohammad MA, Koul S, Egerstedt A, Smith JG, Noc M, Lang I o.a. Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction. Scientific Reports. 2020;10(1). 18663. https://doi.org/10.1038/s41598-020-75399-6

Author

Mohammad, Moman A. ; Koul, Sasha ; Egerstedt, Anna ; Smith, J. Gustav ; Noc, Marko ; Lang, Irene ; Holzer, Michael ; Clemmensen, Peter ; Gidlöf, Olof ; Metzler, Bernhard ; Engstrøm, Thomas ; Erlinge, David. / Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction. I: Scientific Reports. 2020 ; Bind 10, Nr. 1.

Bibtex

@article{922aecb6d0b040a6b6d497420dca6549,
title = "Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction",
abstract = "Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 ± 2 days and 6 months were available as per trial protocol. Using a linear regression model with bootstrap resampling and false discovery rate adjustment we identified five proteins (ST2, interleukin-6, pentraxin-3, interleukin-10, renin, and myoglobin) with elevated values corresponding to larger infarct size or worse LVEF and four proteins (TNF-related apoptosis-inducing ligand, TNF-related activation induced cytokine, interleukin-16, and cystatin B) with values inversely related to LVEF and infarct size, concluding that among 131 circulating inflammatory and cardiovascular proteins in the acute and sub-acute phase of STEMI, nine showed a relationship with infarct size and LVEF post-STEMI, with IL-6 and ST2 exhibiting the strongest association.",
author = "Mohammad, {Moman A.} and Sasha Koul and Anna Egerstedt and Smith, {J. Gustav} and Marko Noc and Irene Lang and Michael Holzer and Peter Clemmensen and Olof Gidl{\"o}f and Bernhard Metzler and Thomas Engstr{\o}m and David Erlinge",
note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
doi = "10.1038/s41598-020-75399-6",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Using proximity extension proteomics assay to identify biomarkers associated with infarct size and ejection fraction after ST-elevation myocardial infarction

AU - Mohammad, Moman A.

AU - Koul, Sasha

AU - Egerstedt, Anna

AU - Smith, J. Gustav

AU - Noc, Marko

AU - Lang, Irene

AU - Holzer, Michael

AU - Clemmensen, Peter

AU - Gidlöf, Olof

AU - Metzler, Bernhard

AU - Engstrøm, Thomas

AU - Erlinge, David

N1 - Publisher Copyright: © 2020, The Author(s).

PY - 2020

Y1 - 2020

N2 - Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 ± 2 days and 6 months were available as per trial protocol. Using a linear regression model with bootstrap resampling and false discovery rate adjustment we identified five proteins (ST2, interleukin-6, pentraxin-3, interleukin-10, renin, and myoglobin) with elevated values corresponding to larger infarct size or worse LVEF and four proteins (TNF-related apoptosis-inducing ligand, TNF-related activation induced cytokine, interleukin-16, and cystatin B) with values inversely related to LVEF and infarct size, concluding that among 131 circulating inflammatory and cardiovascular proteins in the acute and sub-acute phase of STEMI, nine showed a relationship with infarct size and LVEF post-STEMI, with IL-6 and ST2 exhibiting the strongest association.

AB - Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 ± 2 days and 6 months were available as per trial protocol. Using a linear regression model with bootstrap resampling and false discovery rate adjustment we identified five proteins (ST2, interleukin-6, pentraxin-3, interleukin-10, renin, and myoglobin) with elevated values corresponding to larger infarct size or worse LVEF and four proteins (TNF-related apoptosis-inducing ligand, TNF-related activation induced cytokine, interleukin-16, and cystatin B) with values inversely related to LVEF and infarct size, concluding that among 131 circulating inflammatory and cardiovascular proteins in the acute and sub-acute phase of STEMI, nine showed a relationship with infarct size and LVEF post-STEMI, with IL-6 and ST2 exhibiting the strongest association.

U2 - 10.1038/s41598-020-75399-6

DO - 10.1038/s41598-020-75399-6

M3 - Journal article

C2 - 33122738

AN - SCOPUS:85094187136

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 18663

ER -

ID: 269505634