Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol

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Standard

Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol. / Jansen, Charlotte Uldahl; Grier, Katja Egeskov; Andersen, Jens Bo; Hultqvist, Louise Dahl; Nilsson, Martin; Moser, Claus; Graz, Michael; Tolker-Nielsen, Tim; Givskov, Michael; Qvortrup, Katrine.

I: International Journal of Molecular Sciences, Bind 25, Nr. 12, 6737, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jansen, CU, Grier, KE, Andersen, JB, Hultqvist, LD, Nilsson, M, Moser, C, Graz, M, Tolker-Nielsen, T, Givskov, M & Qvortrup, K 2024, 'Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol', International Journal of Molecular Sciences, bind 25, nr. 12, 6737. https://doi.org/10.3390/ijms25126737

APA

Jansen, C. U., Grier, K. E., Andersen, J. B., Hultqvist, L. D., Nilsson, M., Moser, C., Graz, M., Tolker-Nielsen, T., Givskov, M., & Qvortrup, K. (2024). Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol. International Journal of Molecular Sciences, 25(12), [6737]. https://doi.org/10.3390/ijms25126737

Vancouver

Jansen CU, Grier KE, Andersen JB, Hultqvist LD, Nilsson M, Moser C o.a. Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol. International Journal of Molecular Sciences. 2024;25(12). 6737. https://doi.org/10.3390/ijms25126737

Author

Jansen, Charlotte Uldahl ; Grier, Katja Egeskov ; Andersen, Jens Bo ; Hultqvist, Louise Dahl ; Nilsson, Martin ; Moser, Claus ; Graz, Michael ; Tolker-Nielsen, Tim ; Givskov, Michael ; Qvortrup, Katrine. / Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol. I: International Journal of Molecular Sciences. 2024 ; Bind 25, Nr. 12.

Bibtex

@article{86340c8498894feaad320dea2af0d342,

title = "Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol",

abstract = "This paper presents the work performed to transition a lab-scale synthesis (1 g) to a large-scale (400 g) synthesis of the 3-5-diamino-1H-Pyrazole Disperazol, a new pharmaceutical for treatment of antibiotic-resistant Pseudomonas aeruginosa biofilm infections. The potentially hazardous diazotisation step in the lab-scale synthesis was transformed to a safe and easy-to-handle flow chemistry step. Additionally, the paper presents an OSHA-recommended safety assessment of active compound E, as performed by Fauske and Associates, LLC, Burr Ridge, IL, USA.",

keywords = "biofilm, c-di-GMP, dispersal, dust analysis, flow chemistry, large-scale synthesis, preclinical, Pseudomonas aeruginosa, pyrazole, safety",

author = "Jansen, {Charlotte Uldahl} and Grier, {Katja Egeskov} and Andersen, {Jens Bo} and Hultqvist, {Louise Dahl} and Martin Nilsson and Claus Moser and Michael Graz and Tim Tolker-Nielsen and Michael Givskov and Katrine Qvortrup",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

doi = "10.3390/ijms25126737",

language = "English",

volume = "25",

journal = "International Journal of Molecular Sciences (Online)",

issn = "1661-6596",

publisher = "MDPI AG",

number = "12",

}

RIS

TY - JOUR

T1 - Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol

AU - Jansen, Charlotte Uldahl

AU - Grier, Katja Egeskov

AU - Andersen, Jens Bo

AU - Hultqvist, Louise Dahl

AU - Nilsson, Martin

AU - Moser, Claus

AU - Graz, Michael

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

AU - Qvortrup, Katrine

PY - 2024

Y1 - 2024

N2 - This paper presents the work performed to transition a lab-scale synthesis (1 g) to a large-scale (400 g) synthesis of the 3-5-diamino-1H-Pyrazole Disperazol, a new pharmaceutical for treatment of antibiotic-resistant Pseudomonas aeruginosa biofilm infections. The potentially hazardous diazotisation step in the lab-scale synthesis was transformed to a safe and easy-to-handle flow chemistry step. Additionally, the paper presents an OSHA-recommended safety assessment of active compound E, as performed by Fauske and Associates, LLC, Burr Ridge, IL, USA.

AB - This paper presents the work performed to transition a lab-scale synthesis (1 g) to a large-scale (400 g) synthesis of the 3-5-diamino-1H-Pyrazole Disperazol, a new pharmaceutical for treatment of antibiotic-resistant Pseudomonas aeruginosa biofilm infections. The potentially hazardous diazotisation step in the lab-scale synthesis was transformed to a safe and easy-to-handle flow chemistry step. Additionally, the paper presents an OSHA-recommended safety assessment of active compound E, as performed by Fauske and Associates, LLC, Burr Ridge, IL, USA.

KW - biofilm

KW - c-di-GMP

KW - dispersal

KW - dust analysis

KW - flow chemistry

KW - large-scale synthesis

KW - preclinical

KW - Pseudomonas aeruginosa

KW - pyrazole

KW - safety

U2 - 10.3390/ijms25126737

DO - 10.3390/ijms25126737

M3 - Journal article

C2 - 38928443

AN - SCOPUS:85197119622

VL - 25

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 12

M1 - 6737

ER -

ID: 398072077