Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology. / Duwe, Lea; Fouassier, Laura; Lafuente-Barquero, Juan; Andersen, Jesper B.
I: Translational Oncology, Bind 26, 101531, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology
AU - Duwe, Lea
AU - Fouassier, Laura
AU - Lafuente-Barquero, Juan
AU - Andersen, Jesper B.
N1 - Copyright © 2022. Published by Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - Correct actin cytoskeleton organization is vital in the liver organ homeostasis and disease control. Rearrangements of the actin cytoskeleton may play a vital role in the bile duct cells cholangiocytes. An abnormal actin network leads to aberrant cell morphology, deregulated signaling networks and ultimately triggering the development of cholangiocarcinoma (CCA) and paving the route for cancer cell dissemination (metastasis). In this review, we will outline alterations of the actin cytoskeleton and the potential role of this dynamic network in initiating CCA, as well as regulating the course of this malignancy. Actin rearrangements not only occur because of signaling pathways, but also regulate and modify cellular signaling. This emphasizes the importance of the actin cytoskeleton itself as cause for aberrant signaling and in promoting tumorigenic phenotypes. We will highlight the impact of aberrant signaling networks on the actin cytoskeleton and its rearrangement as potential cause for CCA. Often, these exact mechanisms in CCA are limited understood and still must be elucidated. Indeed, focusing future research on how actin affects and regulates other signaling pathways may provide more insights into the mechanisms of CCA development, progression, and metastasis. Moreover, manipulation of the actin cytoskeleton organization highlights the potential for a novel therapeutic area.
AB - Correct actin cytoskeleton organization is vital in the liver organ homeostasis and disease control. Rearrangements of the actin cytoskeleton may play a vital role in the bile duct cells cholangiocytes. An abnormal actin network leads to aberrant cell morphology, deregulated signaling networks and ultimately triggering the development of cholangiocarcinoma (CCA) and paving the route for cancer cell dissemination (metastasis). In this review, we will outline alterations of the actin cytoskeleton and the potential role of this dynamic network in initiating CCA, as well as regulating the course of this malignancy. Actin rearrangements not only occur because of signaling pathways, but also regulate and modify cellular signaling. This emphasizes the importance of the actin cytoskeleton itself as cause for aberrant signaling and in promoting tumorigenic phenotypes. We will highlight the impact of aberrant signaling networks on the actin cytoskeleton and its rearrangement as potential cause for CCA. Often, these exact mechanisms in CCA are limited understood and still must be elucidated. Indeed, focusing future research on how actin affects and regulates other signaling pathways may provide more insights into the mechanisms of CCA development, progression, and metastasis. Moreover, manipulation of the actin cytoskeleton organization highlights the potential for a novel therapeutic area.
U2 - 10.1016/j.tranon.2022.101531
DO - 10.1016/j.tranon.2022.101531
M3 - Review
C2 - 36113344
VL - 26
JO - Translational Oncology
JF - Translational Oncology
SN - 1944-7124
M1 - 101531
ER -
ID: 320008881