Unique splicing pattern of the TCF7L2 gene in human pancreatic islets
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.
Originalsprog | Engelsk |
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Tidsskrift | Diabetologia |
Vol/bind | 52 |
Udgave nummer | 5 |
Sider (fra-til) | 850-4 |
Antal sider | 5 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - maj 2009 |
ID: 46404471