Understanding HAIs: Ally proteins in the fight against cancer
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt
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Understanding HAIs : Ally proteins in the fight against cancer. / Nonboe, Annika W.; Bald, Zuzanna H.; Vogel, Lotte K.
I: FEBS Journal, Bind 289, Nr. 12, 2022, s. 3416-3418.Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt
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TY - JOUR
T1 - Understanding HAIs
T2 - Ally proteins in the fight against cancer
AU - Nonboe, Annika W.
AU - Bald, Zuzanna H.
AU - Vogel, Lotte K.
N1 - Publisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
PY - 2022
Y1 - 2022
N2 - Understanding how HAI-1 and HAI-2 regulate the epithelial serine protease matriptase may hold the key to curing epithelial-derived cancer. HAIs are serine protease inhibitors that inhibit matriptase and have a poorly understood effect on the presence of matriptase protein in cells. In this issue of The FEBS Journal, Yamashita et al. provide much-needed new insights into this effect, describing it as a ‘chaperone-like function’ of HAI-1. However, several observations suggest that matriptase folds correctly without HAIs and that HAIs are not chaperones. We introduce the concept of ‘ally proteins’ to categorize the poorly understood function of HAIs, distinguishing them from chaperones. Comment on: https://doi.org/10.1111/febs.16348.
AB - Understanding how HAI-1 and HAI-2 regulate the epithelial serine protease matriptase may hold the key to curing epithelial-derived cancer. HAIs are serine protease inhibitors that inhibit matriptase and have a poorly understood effect on the presence of matriptase protein in cells. In this issue of The FEBS Journal, Yamashita et al. provide much-needed new insights into this effect, describing it as a ‘chaperone-like function’ of HAI-1. However, several observations suggest that matriptase folds correctly without HAIs and that HAIs are not chaperones. We introduce the concept of ‘ally proteins’ to categorize the poorly understood function of HAIs, distinguishing them from chaperones. Comment on: https://doi.org/10.1111/febs.16348.
KW - ally protein
KW - cancer
KW - chaperone
KW - HAI-1
KW - HAI-2
KW - malignant tumour
KW - matriptase
U2 - 10.1111/febs.16399
DO - 10.1111/febs.16399
M3 - Comment/debate
C2 - 35220685
AN - SCOPUS:85125421867
VL - 289
SP - 3416
EP - 3418
JO - FEBS Journal
JF - FEBS Journal
SN - 1742-464X
IS - 12
ER -
ID: 299491760