Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism
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Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism. / Krog, Sebastian M; Bang, Lia E; Holmvang, Lene; Räder, Sune B; Fanø, Søren; Egstrup, Michael; Hassager, Christian; Høfsten, Dan Eik; Lassen, Jens Flensted; Lindholm, Matias Greve; Engstrøm, Thomas; Kjærgaard, Jesper.
I: Danish Medical Journal, Bind 67, Nr. 7, A11190644, 01.07.2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ultrasound-assisted thrombolysis for acute intermediate-high-risk pulmonary embolism
AU - Krog, Sebastian M
AU - Bang, Lia E
AU - Holmvang, Lene
AU - Räder, Sune B
AU - Fanø, Søren
AU - Egstrup, Michael
AU - Hassager, Christian
AU - Høfsten, Dan Eik
AU - Lassen, Jens Flensted
AU - Lindholm, Matias Greve
AU - Engstrøm, Thomas
AU - Kjærgaard, Jesper
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - INTRODUCTION: Eustachian tube dysfunction (ETD) may result in hearing loss, chronic otitis and cholesteatoma. With advances in treatment options, the identification of patients with obstructive ETD is becoming increasingly important. The objective of this study was to validate a Danish translation of the 7-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7).METHODS: All participants underwent tympanometry, otomicroscopy and completed the ETDQ-7. We included 34 ears from patients with obstructive ETD who had abnormal tympanometry curves but no history of cholesteatoma or adhesive otitis. As a control group, 48 otherwise healthy ears with a normal tympanometry curve were included from patients with known sensorineural hearing loss or normal hearing.RESULTS: A Cronbach's alpha of 0.77 indicated a good internal consistency reliability of the questionnaire. The mean ETDQ-7 score in the obstructive ETD group was 31 versus 13.5 in the control group (p = 0.00). A receiver operating characteristics analysis produced an area under the curve of 94%, showing excellent discriminatory abilities between the groups.CONCLUSIONS: The ETDQ-7 has previously been validated in English, German, Dutch and Portuguese, demonstrating good clinical relevance. The Danish translation of the ETDQ-7 has produced similar results and may be valuable in diagnosing obstructive ETD and in monitoring the effect of balloon dilation of the Eustachian tube.FUNDING: none. The study was approved by the Danish Data Protection Agency (VD-2018-33, I-Suite 6229).
AB - INTRODUCTION: Eustachian tube dysfunction (ETD) may result in hearing loss, chronic otitis and cholesteatoma. With advances in treatment options, the identification of patients with obstructive ETD is becoming increasingly important. The objective of this study was to validate a Danish translation of the 7-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7).METHODS: All participants underwent tympanometry, otomicroscopy and completed the ETDQ-7. We included 34 ears from patients with obstructive ETD who had abnormal tympanometry curves but no history of cholesteatoma or adhesive otitis. As a control group, 48 otherwise healthy ears with a normal tympanometry curve were included from patients with known sensorineural hearing loss or normal hearing.RESULTS: A Cronbach's alpha of 0.77 indicated a good internal consistency reliability of the questionnaire. The mean ETDQ-7 score in the obstructive ETD group was 31 versus 13.5 in the control group (p = 0.00). A receiver operating characteristics analysis produced an area under the curve of 94%, showing excellent discriminatory abilities between the groups.CONCLUSIONS: The ETDQ-7 has previously been validated in English, German, Dutch and Portuguese, demonstrating good clinical relevance. The Danish translation of the ETDQ-7 has produced similar results and may be valuable in diagnosing obstructive ETD and in monitoring the effect of balloon dilation of the Eustachian tube.FUNDING: none. The study was approved by the Danish Data Protection Agency (VD-2018-33, I-Suite 6229).
M3 - Journal article
C2 - 32734887
VL - 67
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 7
M1 - A11190644
ER -
ID: 252154679