Ubiquitylation and degradation of elongating RNA polymerase II

Ubiquitylation and degradation of elongating RNA polymerase II: the last resort

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Standard

Ubiquitylation and degradation of elongating RNA polymerase II : the last resort. / Wilson, Marcus D; Harreman, Michelle; Svejstrup, Jesper Q.

I: BBA Gene Regulatory Mechanisms, Bind 1829, Nr. 1, 01.2013, s. 151-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wilson, MD, Harreman, M & Svejstrup, JQ 2013, 'Ubiquitylation and degradation of elongating RNA polymerase II: the last resort', BBA Gene Regulatory Mechanisms, bind 1829, nr. 1, s. 151-7. https://doi.org/10.1016/j.bbagrm.2012.08.002

APA

Wilson, M. D., Harreman, M., & Svejstrup, J. Q. (2013). Ubiquitylation and degradation of elongating RNA polymerase II: the last resort. BBA Gene Regulatory Mechanisms, 1829(1), 151-7. https://doi.org/10.1016/j.bbagrm.2012.08.002

Vancouver

Wilson MD, Harreman M, Svejstrup JQ. Ubiquitylation and degradation of elongating RNA polymerase II: the last resort. BBA Gene Regulatory Mechanisms. 2013 jan.;1829(1):151-7. https://doi.org/10.1016/j.bbagrm.2012.08.002

Author

Wilson, Marcus D ; Harreman, Michelle ; Svejstrup, Jesper Q. / Ubiquitylation and degradation of elongating RNA polymerase II : the last resort. I: BBA Gene Regulatory Mechanisms. 2013 ; Bind 1829, Nr. 1. s. 151-7.

Bibtex

@article{7e8ca4a6893043a5a5d1c98230b91090,

title = "Ubiquitylation and degradation of elongating RNA polymerase II: the last resort",

abstract = "During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.",

keywords = "Animals, DNA Damage, DNA Repair, Genomic Instability, Humans, Models, Biological, Proteolysis, RNA Polymerase II, Transcription Elongation, Genetic, Ubiquitination",

author = "Wilson, {Marcus D} and Michelle Harreman and Svejstrup, {Jesper Q}",

year = "2013",

month = jan,

doi = "10.1016/j.bbagrm.2012.08.002",

language = "English",

volume = "1829",

pages = "151--7",

journal = "BBA Gene Regulatory Mechanisms",

issn = "1874-9399",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Ubiquitylation and degradation of elongating RNA polymerase II

T2 - the last resort

AU - Wilson, Marcus D

AU - Harreman, Michelle

AU - Svejstrup, Jesper Q

PY - 2013/1

Y1 - 2013/1

N2 - During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

AB - During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

KW - Animals

KW - DNA Damage

KW - DNA Repair

KW - Genomic Instability

KW - Humans

KW - Models, Biological

KW - Proteolysis

KW - RNA Polymerase II

KW - Transcription Elongation, Genetic

KW - Ubiquitination

U2 - 10.1016/j.bbagrm.2012.08.002

DO - 10.1016/j.bbagrm.2012.08.002

M3 - Journal article

C2 - 22960598

VL - 1829

SP - 151

EP - 157

JO - BBA Gene Regulatory Mechanisms

JF - BBA Gene Regulatory Mechanisms

SN - 1874-9399

IS - 1

ER -

ID: 47713381