Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. / Landau, Anne M.; Noer, Ove; Alstrup, Aage Kristian Olsen; Audrain, Hélène; Wegener, Gregers; Gjedde, Albert; Doudet, Doris J.; Winterdahl, Michael.
I: Molecular Imaging and Biology, Bind 22, Nr. 4, 01.08.2020, s. 797-804.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain
AU - Landau, Anne M.
AU - Noer, Ove
AU - Alstrup, Aage Kristian Olsen
AU - Audrain, Hélène
AU - Wegener, Gregers
AU - Gjedde, Albert
AU - Doudet, Doris J.
AU - Winterdahl, Michael
N1 - Publisher Copyright: © 2020, World Molecular Imaging Society.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT2A receptors. Procedures: Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [11C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping. Results: The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Conclusions: Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.
AB - Purpose: Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT2A receptors. Procedures: Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [11C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping. Results: The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former. Conclusions: Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.
KW - Animal
KW - Göttingen minipig
KW - Isoflurane
KW - PET
KW - Propofol
KW - Serotonin
KW - Swine
KW - [C]MDL100,907
U2 - 10.1007/s11307-020-01476-x
DO - 10.1007/s11307-020-01476-x
M3 - Journal article
C2 - 31993926
AN - SCOPUS:85078916576
VL - 22
SP - 797
EP - 804
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
SN - 1536-1632
IS - 4
ER -
ID: 286485318