Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures

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Standard

Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures. / Junker, Niels; Kvistborg, Pia; Køllgaard, Tania; Straten, Per thor; Andersen, Mads Hald; Svane, Inge Marie.

I: Cellular Immunology, Bind 273, Nr. 1, 2012, s. 1-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Junker, N, Kvistborg, P, Køllgaard, T, Straten, PT, Andersen, MH & Svane, IM 2012, 'Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures', Cellular Immunology, bind 273, nr. 1, s. 1-9. https://doi.org/10.1016/j.cellimm.2011.12.004

APA

Junker, N., Kvistborg, P., Køllgaard, T., Straten, P. T., Andersen, M. H., & Svane, I. M. (2012). Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures. Cellular Immunology, 273(1), 1-9. https://doi.org/10.1016/j.cellimm.2011.12.004

Vancouver

Junker N, Kvistborg P, Køllgaard T, Straten PT, Andersen MH, Svane IM. Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures. Cellular Immunology. 2012;273(1):1-9. https://doi.org/10.1016/j.cellimm.2011.12.004

Author

Junker, Niels ; Kvistborg, Pia ; Køllgaard, Tania ; Straten, Per thor ; Andersen, Mads Hald ; Svane, Inge Marie. / Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures. I: Cellular Immunology. 2012 ; Bind 273, Nr. 1. s. 1-9.

Bibtex

@article{ae098d837e49418e9e5392925e6de04b,

title = "Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures",

abstract = "Ex vivo expanded tumor infiltrating lymphocytes (TILs) from malignant melanoma (MM) and head & neck squamous cell carcinoma (HNSCC) share a similar oligoclonal composition of T effector memory cells, with HLA class I restricted lysis of tumor cell lines. In this study we show that ex vivo expanded TILs from MM and HNSCC demonstrate a heterogeneous composition in frequency and magnitude of tumor associated antigen specific populations by Elispot IFN¿ quantitation. TILs from MM and HNSCC shared reactivity towards NY ESO-1, cyclin B1 and Bcl-x derived peptides. Additionally we show that dominating T-cell clones and functionality persists through out expansion among an oligoclonal composition of T-cells. Our findings mirror prior results on the oligoclonal composition of TIL cultures, further indicating a potential for a broader repertoire of specific effector cells recognizing the heterogeneous tumors upon adoptive transfer; increasing the probability of tumor control by minimizing immune evasion by tumor cell escape variants.",

author = "Niels Junker and Pia Kvistborg and Tania K{\o}llgaard and Straten, {Per thor} and Andersen, {Mads Hald} and Svane, {Inge Marie}",

year = "2012",

doi = "10.1016/j.cellimm.2011.12.004",

language = "English",

volume = "273",

pages = "1--9",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press",

number = "1",

}

RIS

TY - JOUR

T1 - Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures

AU - Junker, Niels

AU - Kvistborg, Pia

AU - Køllgaard, Tania

AU - Straten, Per thor

AU - Andersen, Mads Hald

AU - Svane, Inge Marie

PY - 2012

Y1 - 2012

N2 - Ex vivo expanded tumor infiltrating lymphocytes (TILs) from malignant melanoma (MM) and head & neck squamous cell carcinoma (HNSCC) share a similar oligoclonal composition of T effector memory cells, with HLA class I restricted lysis of tumor cell lines. In this study we show that ex vivo expanded TILs from MM and HNSCC demonstrate a heterogeneous composition in frequency and magnitude of tumor associated antigen specific populations by Elispot IFN¿ quantitation. TILs from MM and HNSCC shared reactivity towards NY ESO-1, cyclin B1 and Bcl-x derived peptides. Additionally we show that dominating T-cell clones and functionality persists through out expansion among an oligoclonal composition of T-cells. Our findings mirror prior results on the oligoclonal composition of TIL cultures, further indicating a potential for a broader repertoire of specific effector cells recognizing the heterogeneous tumors upon adoptive transfer; increasing the probability of tumor control by minimizing immune evasion by tumor cell escape variants.

AB - Ex vivo expanded tumor infiltrating lymphocytes (TILs) from malignant melanoma (MM) and head & neck squamous cell carcinoma (HNSCC) share a similar oligoclonal composition of T effector memory cells, with HLA class I restricted lysis of tumor cell lines. In this study we show that ex vivo expanded TILs from MM and HNSCC demonstrate a heterogeneous composition in frequency and magnitude of tumor associated antigen specific populations by Elispot IFN¿ quantitation. TILs from MM and HNSCC shared reactivity towards NY ESO-1, cyclin B1 and Bcl-x derived peptides. Additionally we show that dominating T-cell clones and functionality persists through out expansion among an oligoclonal composition of T-cells. Our findings mirror prior results on the oligoclonal composition of TIL cultures, further indicating a potential for a broader repertoire of specific effector cells recognizing the heterogeneous tumors upon adoptive transfer; increasing the probability of tumor control by minimizing immune evasion by tumor cell escape variants.

U2 - 10.1016/j.cellimm.2011.12.004

DO - 10.1016/j.cellimm.2011.12.004

M3 - Journal article

C2 - 22230732

VL - 273

SP - 1

EP - 9

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -

ID: 40196979