Tuft Cells and Their Role in Intestinal Diseases
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Tuft Cells and Their Role in Intestinal Diseases. / Hendel, Sebastian Kjærgaard; Kellermann, Lauge; Hausmann, Annika; Bindslev, Niels; Jensen, Kim Bak; Nielsen, Ole Haagen.
I: Frontiers in Immunology, Bind 13, 822867, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Tuft Cells and Their Role in Intestinal Diseases
AU - Hendel, Sebastian Kjærgaard
AU - Kellermann, Lauge
AU - Hausmann, Annika
AU - Bindslev, Niels
AU - Jensen, Kim Bak
AU - Nielsen, Ole Haagen
N1 - Copyright © 2022 Hendel, Kellermann, Hausmann, Bindslev, Jensen and Nielsen.
PY - 2022
Y1 - 2022
N2 - The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to helminthic and protozoan infection has further spurred the exploration of these rare chemosensory epithelial cells. Although very sparse in number, tuft cells are now known as important sentinels in the gastrointestinal tract as they monitor intestinal content using succinate as well as sweet and bitter taste receptors. Upon stimulation, tuft cells secrete a broad palette of effector molecules, including interleukin-25, prostaglandin E 2 and D 2, cysteinyl leukotriene C 4, acetylcholine, thymic stromal lymphopoietin, and β-endorphins, some of which with immunomodulatory functions. Tuft cells have proven indispensable in anti-helminthic and anti-protozoan immunity. Most studies on tuft cells are based on murine experiments using double cortin-like kinase 1 (DCLK1) as a marker, while human intestinal tuft cells can be identified by their expression of the cyclooxygenase-1 enzyme. So far, only few studies have examined tuft cells in humans and their relation to gut disease. Here, we present an updated view on intestinal epithelial tuft cells, their physiology, immunological hub function, and their involvement in human disease. We close with a discussion on how tuft cells may have potential therapeutic value in a clinical context.
AB - The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to helminthic and protozoan infection has further spurred the exploration of these rare chemosensory epithelial cells. Although very sparse in number, tuft cells are now known as important sentinels in the gastrointestinal tract as they monitor intestinal content using succinate as well as sweet and bitter taste receptors. Upon stimulation, tuft cells secrete a broad palette of effector molecules, including interleukin-25, prostaglandin E 2 and D 2, cysteinyl leukotriene C 4, acetylcholine, thymic stromal lymphopoietin, and β-endorphins, some of which with immunomodulatory functions. Tuft cells have proven indispensable in anti-helminthic and anti-protozoan immunity. Most studies on tuft cells are based on murine experiments using double cortin-like kinase 1 (DCLK1) as a marker, while human intestinal tuft cells can be identified by their expression of the cyclooxygenase-1 enzyme. So far, only few studies have examined tuft cells in humans and their relation to gut disease. Here, we present an updated view on intestinal epithelial tuft cells, their physiology, immunological hub function, and their involvement in human disease. We close with a discussion on how tuft cells may have potential therapeutic value in a clinical context.
U2 - 10.3389/fimmu.2022.822867
DO - 10.3389/fimmu.2022.822867
M3 - Review
C2 - 35237268
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 822867
ER -
ID: 299346376